摘要
随着材料学、生物学领域研究的不断进步,集合材料学和生物学双重特性的生物材料的重要性日益凸显。目前生物材料在组织工程、制药工程和再生医学等领域应用较为广泛。在因外伤、肿瘤侵袭、先天畸形等因素造成的骨缺损修复领域,已涌现出很多不同的生物材料,它们在表面电荷、表面润湿性、表面成分、免疫调节等方面各自具有不同的特性,导致修复效果各具差异。本文就生物材料表面电荷对骨形成的影响,以及在生物材料表面引入电荷的方法展开论述,为生物材料表面电荷分布促进骨形成奠定理论基础,以期今后更好地服务于临床研究。
With the continuous progress of materials science and biology, the significance of biomaterials with dual characteristics of materials science and biology is keeping on increasing. Nowadays, more and more biomaterials are being used in tissue engineering, pharmaceutical engineering and regenerative medicine. In repairing bone defects caused by trauma, tumor invasion, congenital malformation and other factors, a variety of biomaterials have emerged with different characteristics, such as surface charge, surface wettability, surface composition, immune regulation and so on,leading to significant differences in repair effects. This paper mainly discusses the influence of surface charge of biomaterials on bone formation and the methods of introducing surface charge, aiming to promote bone formation by changing the charge distribution on the surface of the biomaterials to serve the clinical treatment better.
作者
王绍泰
宋东升(综述)
乔春燕(审校)
WANG Shaotai;SONG Dongsheng;QIAO Chunyan(Department of Orthodontics,Hospital of Stomatology,Jilin University,Changchun 130021,P.R.China;Department of Pathology,Hospital of Stomatology,Jilin University,Changchun 130021,P.R.China;Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling,Changchun 130021,P.R.China)
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2021年第6期1229-1234,共6页
Journal of Biomedical Engineering
基金
国家自然科学基金青年基金(81400488)
吉林省卫生厅项目(2018J073)
吉林省财政厅项目(JCSZ2020304-16)。
关键词
生物材料
骨缺损
表面电荷
表面润湿性
表面成分
免疫调节
biomaterials
bone defects
surface charge
surface wettability
surface composition
immune regulation
