摘要
目的探讨高频重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)治疗慢性精神分裂症患者认知功能的疗效及安全性。方法以2019年6月-2020年12月中山市第三人民医院收治的60例慢性精神分裂症患者为研究对象。根据随机数字表法分为对照组与观察组。对照组用奥氮平治疗,观察组加用rTMS治疗。对比两组疗效及安全性。结果观察组总有效率为90.00%,高于对照组66.67%,P<0.05。两组治疗后阳性与阴性症状量表(PANSS)阳性症状、阴性症状、一般精神病理评分及总分均降低,观察组低于对照组,P<0.05。两组治疗后神经心理状态评定量表(RBANS)即刻记忆、视觉空间结构、语言、注意、延迟记忆评分及总分升高,观察组高于对照组,P<0.05。干预4周后观察组患者副反应量表(TESS)评分为(3.19±1.65)分,低于对照组(4.78±1.45)分,P<0.05。结论rTMS治疗慢性精神分裂症患者的疗效理想,可改善患者症状,提升认知功能,且安全性较高。
Objective:To investigate the efficacy and safety of high-frequency repetitive transcranial magnetic stimulation(rTMS)in the treatment of cognitive function in patients with chronic schizophrenia.Methods:From June 2019 to December 2020,60 patients with chronic schizophrenia admitted to Zhongshan Third People's Hospital were taken as subjects,and according to the number table method,they were randomly divided into control group and observation group.The control group was treated with olanzapine,and the observation group was treated with rTMS.The efficacy and safety of the two groupswere compared.Results:The total effective rate of the observation group was 90.00%(27/30),which was higher than that of the control group(66.67%,20/30),(P<0.05).The positive and negative symptom scale(PANSS)positive symptoms,negative symptoms,general psychopathological scores and total scores of the two groups decreased after treatment,and the observation group was lower than the control group(P<0.05).The scores of immediate memory,visual spatial structure,language,attention,and delayed memory and total scores of the two groups increased after treatment on the Neuropsychological State Rating Scale(RBANS),and they were higher in the observation group than those in the control group(P<0.05).After 4 weeks of intervention,the TESS score of the observation group was(3.19±1.65)points,which was lower than that in the control group[(4.78±1.45)points,P<0.05].Conclusion:rTMS has an ideal curative effect in the treatment of chronic schizophrenia,which can improve patients'symptoms,enhance cognitive function,and has high safety.
作者
余金鸣
万静
陈佳伟
牛亚辉
Yu Jinming;Wan Jing;Chen Jiawei;Niu Yahui(Zhongshan Third People's Hospital,Zhongshan 528451,China)
出处
《山东第一医科大学（山东省医学科学院）学报》
2021年第11期829-832,共4页
Journal of Shandong First Medical University ＆ Shandong Academy of Medical Sciences
基金
中山市社会公益与基础研究项目(医疗卫生)(2020B1103)。
关键词
高频重复经颅磁刺激
慢性精神分裂症
认知功能
疗效
high frequency repetitive transcranial magnetic stimulation
chronic schizophrenia
cognitive function
curative effect
