摘要
【目的】探讨傅山引火汤加减治疗肾阳亏虚型复发性口腔溃疡(ROU)的有效性及安全性。【方法】将70例肾阳亏虚型ROU患者随机分为试验组和对照组,每组各35例。对照组给予口服维生素C片联合维生素B2片治疗,试验组给予傅山引火汤加减治疗,疗程为5 d。观察2组患者治疗前后平均溃疡期、疼痛指数视觉模拟量表(VAS)评分和中医证候积分的变化情况,评价2组患者的西医疗效、中医证候疗效及安全性,并进行为期3个月的随访以观察其复发情况。【结果】(1)治疗5 d后,试验组的西医疗效和中医证候疗效的总有效率分别为97.14%(34/35)、97.14%(34/35),对照组分别为65.71%(23/35)、71.43%(25/35),组间比较,试验组的西医疗效和中医证候疗效均明显优于对照组(P<0.05)。(2)治疗后,2组患者的平均溃疡期均较治疗前明显缩短(P<0.05),且试验组对平均溃疡期的缩短作用明显优于对照组(P<0.05)。(3)治疗后,2组患者的疼痛指数VAS评分和中医证候积分均较治疗前明显降低(P<0.05),且试验组对疼痛指数VAS评分和中医证候积分的降低作用均明显优于对照组(P<0.05)。(4)对临床治愈及显效人群进行3个月随访,试验组的复发率为18.54%(5/27),对照组为54.55%(6/11),组间比较,试验组的复发率明显低于对照组(P<0.05)。(5)治疗过程中,2组患者的生命体征(包括体温、呼吸、心率、血压)以及血、尿、大便常规和肝功能、肾功能等安全性指标均无明显异常变化。【结论】应用傅山引火汤加减治疗肾阳亏虚型ROU患者疗效确切,可有效缩短平均溃疡期,降低疼痛指数、中医证候积分和复发率,其中医疗效、西医疗效和远期疗效均优于维生素C片联合维生素B2片治疗的对照组。
Objective To investigate the effectiveness and safety of modified FU Shan Yinhuo Decoction in treating recurrent oral ulcer(ROU)of kidney yang deficiency syndrome. Methods Seventy qualified patients with ROU of kidney yang deficiency syndrome were randomly divided into trial group and control group,35 cases in each group.The control group was given oral use of vitamin C tablets combined with vitamin B2 tablets,and the trial group was given FU Shan Yinhuo Decoction,the course of trial lasting 5 days. The changes of average ulcer period,pain index visual analogue scale(VAS)scores and traditional Chinese medicine(TCM) syndrome scores of the two groups were observed before and after treatment. After treatment,the western medicine efficacy,TCM syndrome efficacy and safety of the two groups were evaluated, and a 3-month follow-up was conducted to observe the recurrence. Results(1)After 5 days of treatment,the total effective rates of western medicine efficacy and TCM syndrome efficacy were 97.14%(34/35) and 97.14%(34/35)respectively in the trial group,and were 65.71%(23/35), and 71.43%(25/35)respectively in the control group. The intergroup comparison showed that the western medicine efficacy and TCM syndrome efficacy of the trial group were significantly superior to those of the control group(P < 0.05).(2)After treatment,the average ulcer period of the two groups was significantly shorter than that before treatment(P < 0.05),and the effect on shortening the average time of ulcer period in the trial group was significantly superior to that in the control group(P < 0.05).(3)After treatment,the pain index VAS scores and TCM syndrome scores in the two groups were significantly decreased compared with those before treatment(P < 0.05),and the effect on lowering the pain index VAS scores and TCM syndrome scores in the trial group was significantly superior to that in the control group(P < 0.05).(4)After 3 months of follow-up for the cured and markedly effective cases,the recurrence rate of the trial group was 18.54%(5/27),and that of the control group was 54.55%(6/11). The intergroup comparison showed that the recurrence rate of the trial group was significantly decreased compared with the control group(P < 0.05).(5)During the treatment, there were no significant abnormal changes in vital signs(including body temperature, respiration, heart rate, blood pressure),routine test for blood,urine and stool,liver function,kidney function and other safety indicators in the two groups. Conclusion Modified FU Shan Yinhuo Decoction exerts certain effect in treating ROU patients with kidney yang deficiency syndrome,which can effectively shorten the average ulcer period,lower the pain index and reduce the TCM syndrome scores and recurrence rate. The TCM efficacy,western medicine efficacy and longterm efficacy of the decoction are all superior to those of the vitamin C tablets combined with vitamin B2 tablets in the control group.
作者
邓巧玲
谭华儒
DENG Qiao-Ling;TAN Hua-Ru(Baoan Traditional Chinese Medicine Hospital Affiliated to Guangzhou University of Chinese Medicine,Shenzhen 518000 Guangdong,China)
出处
《广州中医药大学学报》
CAS
2021年第12期2623-2628,共6页
Journal of Guangzhou University of Traditional Chinese Medicine
关键词
复发性口腔溃疡
肾阳亏虚型
傅山引火汤
平均溃疡期
疼痛指数
recurrent oral ulcer(ROU)
kidney yang deficiency syndrome
FU Shan Yinhuo Decoction
average ulcer period
pain index
