摘要
目的探究注射用丹参多酚酸对急性缺血性脑卒中的疗效及对患者氧化应激指标和血流动力学指标的影响。方法回顾性选取2018年1月—2020年1月新里程安钢总医院收治的急性缺血性脑卒中患者120例为研究对象,将患者随机分为对照组(n=60)和观察组(n=60)。对照组患者采用常规治疗方式,主要包括清除自由基、抗血小板聚集以及改善血液循环等。观察组患者在对照组治疗的基础上加用注射用丹参多酚酸0.13 g溶于0.9%氯化钠注射液250 mL中静脉滴注,1次/d,治疗疗程14 d。通过美国国立卫生研究院卒中量表(NIHSS)评分、改良Rankin量表(mRS)评分评价两组患者治疗前后的神经系统缺损程度,通过丙二醛(MDA)及超氧化物歧化酶(SOD)的测定评价两组患者治疗前后的氧化应激水平,通过经颅多普勒超声(TCD)监测大脑前动脉(ACA)、大脑中动脉(MCA)、大脑后动脉(PCA)血流速度评价两组患者治疗前后的血流动力学变化;对两组患者出现的皮下血肿、颅内出血以及肝肾功能异常等不良反应进行统计分析。结果治疗后观察组的总有效率83.33%,显著高于对照组的56.67%(P<0.05),治疗后两组患者的NIHSS、mRS评分均较治疗前显著下降(P<0.05);且观察组患者降低的更为显著(P<0.05)。与治疗前相比,两组患者的MDA水平均显著下降(P<0.05),SOD水平均显著上升(P<0.05),且观察组的改变幅度更为显著(P<0.05)。与治疗前相比,两组患者的ACA、MCA及PCA血流速度均显著升高(P<0.05),且观察组患者的升高更为显著(P<0.05)。治疗后,与对照组相比,观察组患者的不良反应发生率较低(P<0.05)。结论注射用丹参多酚酸能够显著改善急性缺血性脑卒中患者的神经系统缺损症状,改善预后,且安全性好,具有一定的临床推广应用价值。
Objective To investigate the efficacy of Salvianolic Acids for Injection on acute ischemic stroke and its effects on oxidative stress and hemodynamics.Methods Total 120 patients with acute ischemic stroke treated in New Milestone Angang General Hospital from January 2018 to January 2020 were selected retrospectively.The patients were randomly divided into control group(n=60)and observation group(n=60).The patients in the control group were treated with routine treatment,mainly including scavenging free radicals,anti platelet aggregation and improving blood circulation.On the basis of the treatment of the control group,the patients in the observation group were treated with 0.13 g Salvianolic Acids for Injection and 250 mL of 0.9%sodium chloride injection by intravenous drip,once a day,for 14 days.The neurological deficit of the two groups was evaluated by the National Institutes of Health Stroke Scale(NIHSS)score and the modified Rankin Scale(mRS)score before and after treatment,the oxidative stress levels of the two groups were evaluated by the determination of malondialdehyde(MDA)and superoxide dismutase(SOD).The blood flow velocities of anterior cerebral artery(ACA),middle cerebral artery(MCA),and posterior cerebral artery(PCA)were monitored by transcranial Doppler(TCD)before and after treatment.The adverse reactions such as subcutaneous hematoma,intracranial hemorrhage and abnormal liver and kidney function in two groups were statistically analyzed.Results After treatment,the total effective rate of the observation group was significantly higher than that of the control group(P<0.05).After treatment,the NIHSS and mRS scores of two groups were significantly lower than those before treatment(P<0.05),and the decrease in the observation group was more significant(P<0.05).Compared with before treatment,the level of MDA decreased significantly(P<0.05),the level of SOD increased significantly(P<0.05),and the change range of the observation group was more significant(P<0.05).Compared with before treatment,the blood flow velocities of ACA,MCA and PCA in two groups increased significantly(P<0.05),and the increase in the observation group was more significant(P<0.05).After treatment,the incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion Salvianolic Acids for Injection can significantly improve the symptoms of nervous system defects and prognosis in patients with acute ischemic stroke,and has good safety.It has a certain value of clinical application.
作者
杜培坤
张秀海
金红
DU Peikun;ZHANG Xiuhai;JIN Hong(Department of Neurology,New Milestone Angang General Hospital,Anyang 455000,China)
出处
《药物评价研究》
CAS
2021年第11期2463-2468,共6页
Drug Evaluation Research
