摘要
目的分析环丙沙星联合多索茶碱治疗慢性阻塞性肺疾病(COPD)的临床效果。方法选择医院呼吸科诊治2019年1月-2020年1月诊治的COPD患者79例,采用随机数字法分成对照组和观察组,例数分别有38例和41例。对照组患者接受多索茶碱治疗,观察组患者接受环丙沙星联合多索茶碱治疗。比较两组患者血清炎性因子水平、肺功能、临床疗效和不良反应。结果治疗后,两组患者IFN-y、TNF-α、IL-8水平较治疗前降低,且观察组患者IFN-y、TNF-α、IL-8水平明显低于对照组(P<0.05),并且观察组患者FEV_(1)、FVC和FV_(1)/FVC水平、临床总有效率明显高于对照组(P<0.05)。观察组患者不良发应率高于对照组,但差异比较无统计学意义(P>0.05)。结论环丙沙星联合多索茶碱治疗慢性阻塞性肺疾病患者能明显提升临床疗效,促使肺功能改善,显著抑制炎性因子释放,有利于患者康复,建议使用。
Objective To investigate the efficacy of ciprofloxacin combined with doxofylline in the treatment of chronic obstructive pulmonary disease(COPD).Methods 79 COPD patients in our hospital from January 2019 to January 2020 were enrolled,and divided into two groups by random number table methods.Control group(n=38)received doxofylline,while observation group received ciprofloxacin combined with doxofylline.The levels of serum inflammatory factors,pulmonary function indexes,clinical efficacy and adverse reactions were compared between groups.Results After treatment,there was a decrease in the levels of IFN-y,TNF-αand IL-8 in both groups,and the decrease was more obvious in observation group than in control group(P<0.05).Levels of FEV1,FVC and FEV1/FVC and clinical efficacy of observation group were significantly higher than those of control group(P<0.05).The adverse reaction rate of observation group was slightly higher than that of control group,with no significant difference(P>0.05).Conclusion Ciprofloxacin combined with doxofylline in the treatment of COPD can significantly promote the improvement of pulmonary function,and significantly inhibit the release of inflammatory factors,which is beneficial to the recovery of patients.
作者
程晋红
Cheng Jinhong(Respiratory and Critical Care Medicine Center,the First Affiliated Hospital of Henan University of Science and Technology,Luoyang,Henan 471003)
出处
《辽宁医学杂志》
2021年第6期70-72,共3页
Medical Journal of Liaoning
关键词
环丙沙星
多索茶碱
慢性阻塞性肺疾病
疗效
肺功能
Ciprofloxacin
Doxofylline
Chronic obstructive pulmonary disease
Efficacy
Pulmonary function
