摘要
目的探讨估算肾小球滤过率(estimated glomerular filtration rate,e GFR)对急性轻型缺血性卒中患者尿激酶静脉溶栓后临床结局的预测价值。方法连续收集于2018年6月-2019年12月山东省临清市人民医院卒中中心因急性轻型缺血性卒中行尿激酶静脉溶栓的患者,按照e GFR正常与否分为e GFR正常组(e GFR≥90 ml·min;·1.73m;)与e GFR下降组(e GFR<90 ml·min;·1.73 m;),观察比较两组患者结局指标发生的差异。结果本研究共纳入229例患者,其中e GFR正常组153例,e GFR下降组76例,校正可能的混杂变量后,多因素Logistic回归分析显示,e GFR下降组较e GFR正常组,24 h早期神经功能恶化风险增高[22.4%(19/76)和5.9%(9/153),OR=3.291,95%CI 1.320~8.204,P=0.011]。结论e GFR下降可能会增加尿激酶静脉溶栓后早期24 h神经功能恶化的风险。
Objective To explore the association between estimated glomerular filtration rate (e GFR) and prognosis of mild acute ischemic stroke patients who were treated by intravenous thrombolysis with urokinase.Methods We consecutively screened mild acute ischemic stroke patients who were treated by intravenous thrombolysis with urokinase from June2018 to December 2019 in The people’s hospital of Linqing.According to e GFR value of patients at admission,the eligible patients were divided into two groups:normal e GFR group (e GFR≥90 ml·min;·1.73 m;) and decreased e GFR group(e GFR<90 ml·min;·1.73 m;).Results A total of 229 patients were enrolled,including 153 cases in the normal e G-FR group and 76 cases in the decreased e GFR group.After adjusting for the potential confounders,multivariate logistic regression analysis showed that END at 24 hours[22.4%(19/76) and 5.9%(9/153),OR=3.291,95%CI 1.320~8.204,P=0.011]was higher in the decreased e GFR group than in the normal e GFR group.Conclusion Decreased e GFR may increase the risks of END at 24 hours in mild acute ischemic stroke patients after intravenous thrombolysis with urokinase.
作者
王彬
李晓红
WANG Bin;LI Xiaohong(Jinan Central Hospital,Cheeloo College of Medicine,Shandong University,Jinan 250012,China)
出处
《中风与神经疾病杂志》
CAS
2021年第10期1102-1106,共5页
Journal of Apoplexy and Nervous Diseases
关键词
脑缺血
轻型卒中
血栓溶解疗法
肾小球滤过率
尿激酶
Brain ischemia
Mild acute ischemic stroke
Thrombolytic therapy
Glomerular filtration rate
Urokinase
