摘要
目的探讨微粒化黄体酮与地屈孕酮片治疗排卵障碍型异常子宫出血(AUB-O)的效果及对患者内分泌功能的影响。方法选取2019年5月至2020年12月新余市人民医院收治的117例AUB-O患者作为研究对象,采用随机数字表法将其分为A组(n=39)、B组(n=39)及C组(n=39)。A组给予黄体酮注射液治疗,B组给予微粒化黄体酮胶囊治疗,C组给予地屈孕酮片治疗。比较三组的疗效、治疗前后内分泌功能指标[促黄体生成素(LH)、血清雌二醇(E2)及促卵泡生成素(FSH)]水平变化情况及不良反应发生情况。结果三组的临床总有效率比较,差异无统计学意义(P>0.05);C组治疗后的LH、E2、FSH水平、子宫内膜厚度均低于A组和B组,月经量少于A组和B组,差异有统计学意义(P<0.05);三组均未发生严重不良反应。结论黄体酮与地屈孕酮片治疗AUB-O,均能有效改善患者的内分泌功能及子宫内膜厚度,调节月经量,且安全性好,其中地屈孕酮片的改善作用更为显著,值得临床应用推广。
Objective To explore the effect of Micronized Progesterone and Dydrogesterone Tablets on abnormal uterine bleeding-ovulatory dysfunction(AUB-O)and their influences on endocrine function of patients.Methods A total of 117 AUB-O patients admitted to Xinyu People′s Hospital between May 2019 and December 2020 were selected as subjects and divided into group A(n=39),group B(n=39)and group C(n=39)according to random number table method.Group A was treated with Progesterone injection,group B was treated with Micronized Progesterone Capsules,and group C was treated with Dydrogesterone Tablets.The curative effect,changes in levels of endocrine function indexes(luteinizing hormone[LH],serum estradiol[E2],follicle stimulating hormone[FSH])before and after treatment,and adverse reactions were compared among the three groups.Results There was no significant difference in total clinical effective rate among the three groups(P>0.05).After treatment,the levels of LH,E2,FSH and endometrial thickness in group C were lower than those in group A and group B,and the menstrual volume in group C was lower than that in group A and group B,with statistically significant differences(P<0.05).There were no severe adverse reactions in any group.Conclusion Both Progesterone and Dydrogesterone Tablets can significantly improve endocrine function and endometrial thickness in AUB-O patients,and regulate menstrual volume,with high safety.The improvement effect of Dydrogesterone Tablets is more significant,which is worthy of clinical application and promotion.
作者
杨火梅
宋晓霞
杨秋娟
YANG Huomei;SONG Xiaoxia;YANG Qiujuan(Department of Obstetrics and Gynecology,Xinyu People′s Hospital,Jiangxi Province,Xinyu338000,China)
出处
《中国当代医药》
CAS
2021年第36期146-149,共4页
China Modern Medicine
基金
江西省新余市科技计划项目(20193090818)。
关键词
微粒化黄体酮
地屈孕酮片
排卵障碍型异常子宫出血
内分泌功能
Micronized Progesterone
Dydrogesterone Tablets
Abnormal uterine bleeding-ovulatory dysfunction
Endocrine function
