摘要
病毒感染是患者接受非亲缘脐血移植(UCBT)后非复发死亡的主要原因之一。传统的抗病毒及CD20单克隆抗体等药物,存在耐药和耐受不良等缺点。而通过减停免疫抑制剂控制病毒感染,可能导致患者移植物抗宿主病(GVHD)加重。近年研究结果表明,病毒特异性细胞毒性T淋巴细胞(CTL)是预防和治疗UCBT后病毒感染的安全、有效方法。笔者拟就患者接受UCBT后,其病毒感染的特点及病毒特异性CTL的重建情况,以及病毒特异性CTL治疗病毒感染的机制、制备技术及临床应用的相关研究现状进行总结。
Viral infection is one of main causes of non-relapse death after unrelated cord blood transplantation(UCBT).Traditional antiviral drugs and CD20 monoclonal antibodies have disadvantages of drug resistance and intolerance.Controlling virus infection by reducing immunosuppression may lead to aggravation of graft versus host disease(GVHD).A large number of studies have shown that virus-specific cytotoxicity T lymphocytes(CTL)is a safe and effective method to prevent and treat viral infection after UCBT.This article summarizes research status of characteristics of virus infection and reconstruction of virus-specific CTL in patients after UCBT,as well as principle,preparation technology,clinical applications of virus-specific CTL in treatment of virus infection after UCBT.
作者
陆学琴
周莉
孙自敏
Lu Xueqin;Zhou Li;Sun Zimin(Department of Hematology,First Affiliated Hospital of University of Science and Technology of China,Wannan Medical College,Wuhu 241002,Anhui Province,China;Department of Hematology,First Affiliated Hospital of University of Science and Technology of China,Hefei 230001,Anhui Province,China)
出处
《国际输血及血液学杂志》
CAS
2021年第5期395-400,共6页
International Journal of Blood Transfusion and Hematology
基金
安徽省自然科学基金面上项目(2008085MH249)
安徽省重点研究与开发计划项目(201904a07020094)
中央高校基本科研业务费专项基金资助2019年度"科大新医学"联合基金培育项目(WK9110000138)。
关键词
T淋巴细胞
细胞毒性
脐血干细胞移植
巨细胞病毒感染
爱泼斯坦巴尔病毒感染
移植物抗宿主病
造血干细胞移植
复发
白血病
T-lymphocytes,cytotoxic
Cord blood stem cell transplantation
Cytomegalovirus infections
Epstein-Barr virus infections
Graft vs host disease
Hematopoietic stem cell transplantation
Recurrence
Leukemia
