摘要
进食障碍(eating disorder,ED)是一类患病率高、复发率高、致残率高、社会负担重的慢性难治性精神障碍。进食障碍和情绪调节之间有紧密的联系,越来越多的研究表明进食障碍患者的情绪调节存在异常,情绪失调是进食障碍患者的一个特征,进食障碍患者极易采取异常的进食方式来缓解不良情绪。研究表明,杏仁核、腹侧纹状体、伏隔核、前扣带皮层、脑岛和前额叶皮层及胼胝体前和下组成部分对情绪调节和稳态至关重要,这些脑区结构和功能的改变与ED患者情绪刺激与调节受损息息相关。本综述旨在对ED与异常情绪调节的关系及其神经机制做一个总结并探讨未来研究方向。
Eating disorder(ED)is a kind of chronic refractory mental disorder with high prevalence rate,high recurrence rate,high disability rate and heavy social burden.There is a close relationship between eating disorder and emotional regulation.More and more studies have shown that ED patients have abnormal emotional regulation.Emotional disorder is a feature of ED patients,and ED patients are easy to take abnormal eating ways to relieve their negative emotions.Studies have shown that the amygdala,ventral striatum(VS),nucleus accumbens(NAc),anterior cingulate cortex(ACC),prefrontal cortex(PFC)and subcallosal components(SCC)are crucial for emotion regulation and homeostasis.The structural and functional changes of these brain regions are closely related to emotional stimuli and impaired regulation in patients with ED.The purpose of this review is to summarize the neural mechanism of ED abnormal emotion regulation and discuss the future research direction.
作者
何欠欠
陈珏
He Qianqian;Chen Jue(Department of Clinical Psychology,Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China)
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2021年第12期1147-1152,共6页
Chinese Journal of Behavioral Medicine and Brain Science
基金
国家自然科学基金项目(81771461,82071545)
上海申康医院发展中心临床科技创新项目(SHDC12019129)
上海市2020年度"科技创新行动计划"医学创新研究专项项目(20Y11906500)。
关键词
进食障碍
神经性厌食
神经性贪食
暴食障碍
情绪调节
神经机制
Eating disorder
Anorexia nervosa
Bulimia nervosa
Binge eating disorder
Emotion regulation
Neural mechanism
