摘要
目的探讨齐拉西酮针剂治疗青少年精神分裂症(SCH)急性期激越症状的效果。方法选取2019年7月至2020年7月营口市第四人民医院收治的伴急性激越症状的青少年SCH患者82例,采取随机抽签法将其分为试验组和参照组,每组41例。参照组患者予以氟哌啶醇针剂肌内注射治疗,试验组患者则予以齐拉西酮针剂肌内注射治疗。在治疗期间,评定在用药后6、12、24、48、72 h的阳性和阴性精神症状评定量表兴奋激越项目(PANSS-EC)评分及两组总有效率,并比较两组的不良反应,评估其安全性。结果两组患者用药前的PANSS-EC评分比较,差异无统计学意义(P>0.05);两组患者在用药后6、12、24、48、72 h的PANSS-EC评分低于本组用药前,差异有统计学意义(P<0.05);研究组患者用药后6、12 h的PANSS-EC评分低于参照组,差异有统计学意义(P<0.05);两组患者用药后24、48、72 h的PANSS-EC评分比较,差异无统计学意义(P>0.05);两组的总有效率比较,差异无统计学意义(P>0.05);研究组不良反应发生率低于参照组,差异有统计学意义(P<0.05)。结论在青少年SCH急性期激越症状的治疗中,齐拉西酮针剂能快速控制其激越症状,且能达到与氟哌啶醇针剂相当的效果,用药的安全性方面也更优,临床应用效果良好。
Objective To explore the effect of Ziprasidone Injection on the agitation symptoms of adolescent with schizophrenia(SCH)acute phase.Methods A total of 82 adolescent SCH patients with acute agitation symptoms admitted to the Fourth People′s Hospital of Yingkou from July 2019 to July 2020 were selected as research objects.According to random lottery,they were divided into study group and reference group,with 41 patients in each group.The patients in the reference group were treated with Haloperidol intramuscular injection,and patients in the study group were treated with Ziprasidone intramuscular injection.During the treatment,the excited component of positive and negative syndrome(PANSS-EC)scores and the total effective rate of the two groups at 6,12,24,48 and 72 hours after treatment were evaluated,and the adverse reactions of the two groups were compared to evaluate their safety.Results There was no significant difference in PANSS-EC scores before medication between the two groups(P>0.05).The PANSS-EC scores of the two groups at 6,12,24,48 and 72 hours after medication were lower than those before medication,the differences were statistically significant(P<0.05).The PANSS-EC scores of 6,12 hours after medication in the study group was lower than those in the reference group,the differences were statistically significant(P<0.05).There was no significant difference in PANSS-EC scores between the two groups at 24,48 and 72 hours after treatment(P>0.05).There were no significant difference in the total effective rate between the two groups(P>0.05).The incidence of adverse reactions in the study group was lower than that in the reference group,the difference was statistically significant(P<0.05).Conclusion In the treatment of the agitation symptoms of adolescent with SCH acute phase,Ziprasidone Injection can quickly control the symptoms and achieve the same effect as Haloperidol Injection,with better safety and good clinical application effect.
作者
宋柳
于素维
SONG Liu;YU Suwei(Five Ward,the Fourth People′s Hospital of Yingkou,Liaoning Province,Yingkou115000,China;Psychology Department,Yingkou First Specialized Hospital,Liaoning Province,Yingkou115000,China)
出处
《中国当代医药》
CAS
2022年第1期88-90,94,共4页
China Modern Medicine
基金
辽宁省营口市科学技术项目(20090304)。
关键词
齐拉西酮针剂
青少年
精神分裂症
激越症状
效果
Ziprasidone Injection
Adolescents
Schizophrenia
Agitation symptoms
Effect
