摘要
生物膜的形成是鲍曼不动杆菌产生耐药性的主要原因之一。群体感应系统信号机制的破坏即群体淬灭,是当前治疗鲍曼不动杆菌感染的热点。可以通过抑制信号分子的产生、降解信号分子、阻止信号分子的传导或与受体的结合等群体淬灭方式破坏群体感应系统,抑制鲍曼不动杆菌生物膜的形成,从而降低细菌耐药性。
Biofilm formation is one of the main reasons of drug resistance of Acinetobacter baumannii. Quorum quenching, the destruction of the signal mechanism of quorum sensing system, is a hot spot in the treatment of Acinetobacter baumannii infection. Quorum quenching can destroy the quorum sensing system by ways of inhibiting the generation of signal molecules, degrading signal molecules, and preventing the transmission of signal molecules or binding with receptors, so as to inhibit the formation of biofilm and reduce drug resistance of Acinetobacter baumannii.
作者
董华兴
金怿阳
程冠宇
冯心怡
李国才
DONG Hua-xing;JIN Yi-yang;CHENG Guan-yu;FENG Xin-yi;LI Guo-cai(Yangzhou University Medical College/Jiangsu Key Laboratory of Noncoding RNA/Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases Zoonoses,Yangzhou JIANGSU 225009,China)
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2021年第12期801-805,共5页
Chinese Journal of New Drugs and Clinical Remedies
基金
国家自然科学基金(82073611)
扬州大学大学生学术科技创新项目(X20190730)。
关键词
鲍曼不动杆菌
生物膜
群体感应
群体淬灭
抗药性
细菌
Acinetobacter baumannii
biofilms
quorum sensing
quorum quenching
drug resistance
bacterial
