摘要
目的探讨经尿道膀胱肿瘤电切术(TURBT)术后即刻表柔比星灌注化疗在非肌层浸润性膀胱癌患者中的应用效果。方法根据化疗方式的不同将63例非肌层浸润性膀胱癌患者分为观察组(n=33)和对照组(n=30),均接受TURBT治疗,观察组患者术后即刻给予表柔比星灌注化疗,对照组患者术后1周给予表柔比星灌注化疗。比较两组患者肿瘤新生血管生成相关指标[血管内皮生长因子(VEGF)、成纤维细胞生长因子(FGF)]、免疫功能指标(CD3^(+)、CD4^(+),计算CD4^(+)/CD8^(+))和不良反应发生情况。结果治疗后,两组患者VEGF、FGF水平均低于本组治疗前(P﹤0.05),且观察组患者VEGF、FGF水平均低于对照组(P﹤0.05)。治疗后,两组患者CD3^(+)、CD4^(+)水平和CD4^(+)/CD8^(+)均高于本组治疗前(P﹤0.05)。两组患者不良反应总发生率无明显差异(P﹥0.05)。随访20个月,观察组患者的复发率为12.12%,低于对照组患者的33.33%(P﹤0.05)。结论TURBT术后即刻表柔比星灌注治疗对非肌层浸润性膀胱癌患者的效果良好,能降低其术后复发率,安全性较好。
Objective To explore the effect of immediate epirubicin infusion chemotherapy after transurethral resec-tion of bladder tumor(TURBT)in patients with non-muscular invasive bladder cancer.Method A total of 63 patients with non-muscular invasive bladder cancer were selected and were divided into observation group(n=33)and control group(n=30)according to different chemotherapy methods.Both groups received TURBT,the patients in the observation group were given epirubicin infusion chemotherapy immediately after operation,and the patients in the control group were given epirubicin infusion chemotherapy one week after operation.The tumor angiogenesis related indexes[vascular endothelial growth factor(VEGF),fibroblast growth factor(FGF)],immune function indexes(CD3^(+),CD4^(+),calculate CD4^(+)/CD8^(+))and the incidence of adverse reactions were compared between the two groups.Result After the treatment,the levels of VEGF and FGF of the two groups of patients were lower than those before the treatment(P<0.05),and their levels of the observation group were lower than those of the control group(P<0.05).After the treatment,the levels of CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)of the two groups were higher than those before the treatment(P<0.05).There was no signif-icant difference in the total incidence of adverse reactions between the two groups(P>0.05).After 20 months of follow up,the recurrence rate of the observation group was 12.12%,which was lower than 33.33%of the control group(P<0.05).Conclusion Epirubicin perfusion therapy immediately after TURBT has a good effect on patients with non-muscu-lar invasive bladder cancer,can reduce the recurrence rate after surgery,and has good safety.
作者
苟泓燊
郑红岗
段中琪
GOU Hongshen;ZHENG Honggang;DUAN Zhongqi(Department of Urology,Xi’an People’s Hospital(Xi’an Fourth Hospital),Xi’an 710004,Shaanxi,China)
出处
《癌症进展》
2021年第22期2343-2346,共4页
Oncology Progress
关键词
非肌层浸润性膀胱癌
膀胱灌注化疗
经尿道膀胱肿瘤电切术
表柔比星
non-muscular invasive bladder cancer
bladder infusion chemotherapy
transurethral resection of bladder tumor
epirubicin
