摘要
目的研究益气养阴复方联合穴位雷火灸辅助治疗Ⅲ~Ⅳ期原发性肺癌气阴两虚证的临床效果。方法选取2018年3月至2019年6月新郑市中医院收治的112例Ⅲ~Ⅳ期原发性肺癌气阴两虚证患者,依照治疗方案分为观察组、对照组,各56例。给予两组患者常规干预,对照组接受培美曲塞联合铂类治疗,观察组在对照组基础上接受益气养阴复方联合穴位雷火灸治疗。比较两组临床总有效率、免疫因子[淋巴细胞表面抗原(CD3^(+)、CD4^(+))、粒细胞集落刺激因子(G-CSF)、中粒-巨噬细胞集落刺激因子(GM-CSF)]水平、毒副反应、生存率。结果治疗后,观察组临床总有效率(71.43%)高于对照组(51.79%)(P<0.05);治疗后,观察组CD3^(+)、CD4^(+)、G-CSF、GM-CSF水平均高于对照组(P<0.05);观察组骨髓抑制发生率(3.57%)低于对照组(7.14%)(P<0.05);观察组1 a生存率(53.57%)、2 a生存率(33.93%)高于对照组(44.64%、23.22%)(P<0.05)。结论益气养阴复方、穴位雷火灸联合化疗治疗Ⅲ~Ⅳ期原发性肺癌气阴两虚证能提高临床效果,减轻免疫功能损伤,提高生存期限,减少骨髓抑制情况的发生。
Objective To study the clinical effect of Yiqi Yangyin compound combined with acupoint thunder fire moxibustion in the treatment of stageⅢ-Ⅳprimary lung cancer with both qi and yin deficiency syndrome.Methods A total of 112 patients with primary lung cancer stageⅢ-Ⅳprimary lung cancer with Qi and Yin deficiency syndrome from March 2018 to June 2019 were selected from Xinzheng Hospital of Traditional Chinese Medicine.According to treatment plans,they were divided into observation group and control group,with 56 cases in each.Both groups were given conventional intervention.The control group was treated with pemetrexed combined with platinum,and the observation group was treated with acupoint thunder fire moxibustion combined with Yiqi Yangyin compound on the basis of the control group.The clinical total effective rate,immune factors[lymphocyte surface antigen(CD3+,CD4+),granulocyte colony stimulating factor(G-CSF),neutrophil-macrophage colony stimulating factor(GM-CSF)],toxicities response and survival rate between the two groups were compared.Results After treatment,the total clinical effective rate(71.43%)of the observation group was higher than that of the control group(51.79%)(P<0.05).After treatment,the levels of CD3+,CD4+,G-CSF,and GM-CSF in the observation group were all higher than those of the control group(P<0.05).The incidence of bone marrow suppression in the observation group(3.57%)was lower than that in the control group(7.14%)(P<0.05).The 1-year survival rate(53.57%)and 2-year survival rate(33.93%)of the observation group were higher than those of the control group(44.64%,23.22%)(P<0.05).Conclusion Yiqi Yangyin compound,acupoint thunder fire moxibustion and chemotherapy can improve the clinical efficacy of primary lung cancer stageⅢ-Ⅳwith deficiency of both Qi and Yin,relieve immune function damage,improve survival time,and reduce the occurrence of bone marrow suppression.
作者
肖琼
张晓
牛坤伟
XIAO Qiong;ZHANG Xiao;NIU Kunwei(Department of Internal Medicine,Xinzheng Hospital of Traditional Chinese Medicine,Zhengzhou 451100,China)
出处
《河南医学研究》
CAS
2022年第1期156-159,共4页
Henan Medical Research
关键词
原发性肺癌
益气养阴复方
穴位雷火灸
气阴两虚证
primary lung cancer
Yiqi Yangyin compound
acupoint thunder fire moxibustion
Qi and Yin deficiency syndrome
