摘要
目的基于“古今医案云平台(V2.3.8)”探讨中药保留灌肠治疗肛窦炎的用药规律。方法检索中国知网(CNKI)、维普中文期刊服务平台(VIP)、万方数据知识服务平台(WanFang Data)、中国生物医学文献数据库(CBM)收录的中药保留灌肠治疗肛窦炎的相关文献,发表时间为建库至2021年3月4日,借助“古今医案云平台(V2.3.8)”建立中药处方数据库,并采用“数据挖掘分析”模块进行药物频次分析、性味归经分析、关联规则分析,采用“多维分析”模块进行核心药物分析、聚类分析。结果①共纳入58篇文献,包含58首方剂,涉及108味中药。②高频使用的中药有黄柏、黄连、大黄、苦参、金银花,药性以寒、温为主,药味多苦、辛、甘,且以归肝、胃、心、脾、大肠、肺经者多见。③关联分析得到14个药物组合,高频药对有苦参-黄柏、金银花-黄柏、地榆-黄柏等。④核心用药网络由18味中药组成,核心配伍网络由2组药物构成,聚类分析得到3类药物。结论中药保留灌肠治疗肛窦炎讲究寒温并用、肝脾同调,用药以清热解毒药、清热燥湿药、清热凉血药、活血止痛药为主,反映了肛窦炎“湿、热、毒、瘀”的病机特点。
Objective To explore the medication rules of retention enema with traditional Chinese medicine(TCM)in treating anal sinusitis based on the ancient and modern medical case cloud platform(V2.3.8).Methods Related literatures of retention enema with TCM in the treatment of anal sinusitis published from the establishment of the databases to March 4,2021 were retrieved from CNKI,VIP,WanFang Data,VIP,China Biomedical Literature Service Platform(CBM).A database of traditional Chinese medicine prescriptions was established based on the ancient and modern medical case cloud platform(V2.3.8).The“data mining analysis”module was used for the analysis of traditional Chinese herbal medicines(TCHMs)use frequency,nature,taste,tropism and correlation rules,and the“multidimensional analysis”module was used for the core drug analysis and cluster analysis.Results①Finally 58 articles were included,involving 58 prescriptions and 108 TCHMs.②TCHMs with high use frequency were Phellodendron chinense Schneid,Coptis Rhizoma,Rhei Radix et Rhizoma,Sophorae Flavescentis Radix and Lonicerae Japonicae Flos,which have cold and warm properties,bitter,pungent and sweet tastes,and enter the liver,stomach,heart,spleen,large intestine and lung meridians.③Fourteen TCHM combinations were obtained through correlation analysis,and the TCHM pairs with high use frequency were Sophorae Flavescentis Radix-Phellodendron chinense Schneid,Lonicerae Japonicae Flos-Phellodendron chinense Schneid,and Sanguisorbae Radix-Phellodendron chinense Schneid.④The core medication network was composed of 18 TCHMs,and the core compatibility network was composed of 2 groups of TCHMs.There were 3 categories of TCHMs obtained through cluster analysis.Conclusion The application of retention enema with TCM to the treatment of anal sinusitis stresses the combined use of cold and warm medicines,and simultaneous regulation of the liver and spleen.The TCHMs used are mainly heat-clearing and detoxifying medicinals,heat-clearing and dampness-drying medicinals,heat-clearing and blood-cooling medicinals,and blood-activating and pain-relieving medicinals,reflecting the pathological characteristics of anal sinusitis:“dampness,heat,toxicity and stasis”.
作者
梁彪
施展
高家治
徐朝辉
王建东
LIANG Biao;SHI Zhan;GAO Jiazhi;XU Zhaohui;WANG Jiandong(Department of Anorectal Surgery,Putuo Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China)
出处
《上海中医药杂志》
2021年第11期27-30,38,共5页
Shanghai Journal of Traditional Chinese Medicine
基金
国家自然科学基金项目(81704080)
上海市卫健委“杏林新星”计划项目(ZY〔2018-2020〕-RCPY-3020)。
关键词
肛窦炎
中药灌肠
数据挖掘
古今医案云平台
anal sinusitis
retention enema with traditional Chinese medicine
data mining
ancient and modern medical case cloud platform
