摘要
黏液表皮样癌(MEC)是口腔颌面部常见的上皮性恶性肿瘤。由于黏液表皮样癌具有高发病率和病死率,以及高转移率和复发率,因此患者的生活质量一直是治疗和康复过程中的一个严重问题。上皮细胞黏附分子(EpCAM)高表达于快速生长的上皮肿瘤中,与上皮性恶性肿瘤密切相关,参与上皮性恶性肿瘤细胞黏附、信号传导、迁移和增殖,并与肿瘤的预后密切相关。当细胞与细胞间发生黏附作用时,EpCAM聚集于细胞膜表面,可改变细胞内的微环境,影响MEC的预后及转移。EpCAM参与肿瘤的发生、发展,可为MEC的早期诊断及预后评估提供新的参考依据。
Mucoepidermoid carcinoma(MEC)is a common epithelial malignant tumor in oral and maxillofacial region.Due to the high morbidity,mortality and metastasis rates,the quality of life of MEC patients has always been a serious problem in the process of treatment and rehabilitation.Epithelial cell adhesion molecule(EpCAM)is highly expressed in the fast-growing epithelial tumors,which is closely correlated with the epithelial malignant tumors.It is involved in the epithelial malignant tumor cell adhesion,signal transduction,migration and proliferation,and is intimately associated with the prognosis of tumors.When cell-to-cell adhesion occurs,EpCAM aggregates on the surface of cell membrane,which can change the intracellular microenvironment and affect the prognosis and metastasis of MEC.EpCAM is involved in the incidence and development of tumors,which can provide novel reference for the early diagnosis and prognostic assessment of MEC.
作者
聂宇
夏鹏
袁倩
吴发印
Nie Yu;Xia Peng;Yuan Qian;Wu Fayin(Department of Oral and Maxillofacial Surgery,the Fifth Affiliated Hospital(Zhuhai)of Zunyi Medical University,Zhuhai 519000,China)
出处
《新医学》
CAS
2022年第1期14-17,共4页
Journal of New Medicine
关键词
黏液表皮样癌
上皮细胞黏附分子
综述
Mucoepidermoid carcinoma
Epithelial cell adhesion molecule
Review
