摘要
目的探讨冻干重组人脑利钠肽(商品名:新活素)联合左西孟旦治疗慢性心力衰竭(心衰)急性发作的临床疗效。方法84例慢性心衰急性发作患者为研究对象,依据随机数字表法分为对照组与观察组,各42例。对照组给予新活素治疗,观察组给予新活素联合左西孟旦治疗。比较两组治疗效果、不良反应发生情况、治疗前后临床相关指标改善情况。结果观察组治疗总优良率97.62%高于对照组的83.33%,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。治疗后,观察组尿量(1320.50±200.50)ml/d、血尿素氮(BUN)(6.50±1.15)mmol/L、LVEF(49.30±5.50)%均优于对照组的(891.50±165.50)ml/d、(14.66±3.30)mmol/L、(42.80±4.20)%,差异有统计学意义(P<0.05)。结论对比单纯新活素治疗,新活素联合左西孟旦治疗慢性心衰急性发作可促进患者心功能、排尿量改善,提升治疗效果,安全性高。
Objective To discuss the clinical efficacy of recombinant human brain natriuretic peptide(trade name:Xinhuosu)combined with levosimendan in the treatment of acute attack of chronic heart failure.Methods A total of 84 patients with acute attack of chronic heart failure were taken as the study subjects.According to the random numerical table,they were divided into control group and observation group,with 42 cases in each group.The control group was treated with Xinhuosu,and the observation group was treated with Xinhuosu and levosimendan.The therapeutic effect,occurrence of adverse reactions,and improvement of clinical related indicators before and after treatment were compared between the two groups.Results The total excellent-good rate of treatment 97.62%in the observation group was higher than 83.33%in the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).After treatment,the urinary output(1320.50±200.50)ml/d,blood urea nitrogen(BUN)(6.50±1.15)mmol/L,and LVEF(49.30±5.50)%of the observation group were better than(891.50±165.50)ml/d,(14.66±3.30)mmol/L,and(42.80±4.20)%of the control group,and the difference was statistically significant(P<0.05).Conclusion Compared with the treatment of Xinhuosu alone,combined with levosimendan for the treatment of acute attack of chronic heart failure can improve the patient’s heart function and urinary output,improve the therapeutic effect,and have high safety.
作者
付春英
FU Chun-ying(Department of Cardiology,Dandong People’s Hospital,Dandong 118000,China)
出处
《中国现代药物应用》
2021年第24期130-132,共3页
Chinese Journal of Modern Drug Application
关键词
冻干重组人脑利钠肽
左西孟旦
慢性心力衰竭
心功能
尿量
血尿素氮
Recombinant human brain natriuretic peptide
Levosimendan
Chronic heart failure
Heart function
Urinary output
Blood urea nitrogen
