摘要
巨噬细胞是重要的先天性免疫细胞,在炎症刺激下,巨噬细胞可以迅速应答并通过代谢重编程产生大量代谢物。衣康酸是源于三羧酸循环的免疫调节衍生物,具有抗氧化和抗炎作用。近年研究证实衣康酸可促进巨噬细胞由M1型向M2型转化,但其机制复杂,可能与烷基化Kelch样ECH相关蛋白1(Keap1)残基激活核因子E2相关因子2(Nrf2),阻止核转录因子-κB抑制因子ζ(IκBζ)翻译,抑制琥珀酸脱氢酶(SDH)和活性氧(ROS)生成以及下调有氧糖酵解水平等有关。本文就衣康酸的代谢途径与免疫应答之间的关系,及其对巨噬细胞炎症反应调控机制的最新研究进展进行阐述,以期为衣康酸的临床应用提供依据,并为与炎症相关疾病的治疗提供新思路和新策略。
Macrophages are important innate immune cells.Under inflammatory stimulation,macrophages rapidly respond and subsequently produce large amounts of cellular metabolites through metabolic reprogramming.Itaconate is an immunomodulatory derivative from the tricarboxylic acid cycle which has antioxidative and anti-inflammatory effects.In recent years,it has been reported that itaconate promotes the transition of macrophage phenotype from M1 to M2 and the underlying mechanism may include the activation of nuclear factor E2-related factor 2(Nrf2)by alkylation of Kelch-like ECH-associated protein 1(Keap1),inhibition of succinate dehydrogenase(SDH)and reactive oxygen species(ROS),blockade of the inhibitorζof nuclear factor-κB(IκBζ)translation and inhibition of aerobic glycolysis.In this review,we describe the metabolic pathways of itaconate,clarify the relationship between itaconate and the immune response,and summarize the latest researches about the roles of itaconate on regulating the inflammatory response in macrophages in order to provide the basis for the clinical use of itaconate and new strategies for the treatment of inflammatory diseases.
作者
吴雨桐
郑莉
杨浩
吕欣
Wu Yutong;Zheng Li;Yang Hao;Lyu Xin(Department of Anesthesiology,Shanghai Pulmonary Hospital of Tongji University,Shanghai 200433,China)
出处
《中华危重病急救医学》
CAS
CSCD
北大核心
2021年第11期1388-1392,共5页
Chinese Critical Care Medicine
基金
国家自然科学基金(81871601,82000085)。
关键词
衣康酸
巨噬细胞
免疫代谢
炎症反应
Itaconate
Macrophage
Immunemetabolism
Inflammation response
