摘要
目的探讨一清胶囊联合西帕依固龈液治疗牙龈炎的临床疗效。方法选取2019年4月—2021年4月在中国人民武装警察部队特色医学中心口腔科就诊治疗的118例牙龈炎患者,根据随机数字表法分为对照组和治疗组,每组各59例。对照组患者给予西帕依固龈液,5 m L/次,含漱2~3 min,3次/d。治疗组在对照组的基础上口服一清胶囊,2粒/次,3次/d。两组患者连续服用药物7 d。观察两组的临床疗效,比较两组临床症状好转时间、牙菌斑指数(PLI)评分、龈沟出血指数(SBI)评分、牙龈指数(GI)评分、龈沟液炎性因子水平。结果治疗后,治疗组患者总有效率是98.31%,显著高于对照组的83.05%(P<0.05)。治疗后,治疗组牙龈出血、牙龈红肿、牙龈疼痛、口腔异味等症状好转时间均短于对照组(P<0.05)。治疗后,两组PLI、SBI、GI评分均显著低于同组治疗前(P<0.05);治疗后,治疗组牙龈相关评分显著低于对照组(P<0.05)。治疗后,两组患者牙龈沟液炎性因子白细胞介素17(IL-17)、可溶性细胞间黏附分子1(sICAM-1)、肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)水平均显著降低(P<0.05);且治疗后,治疗组龈沟液炎性因子水平显著低于对照组(P<0.05)。结论一清胶囊联合西帕依固龈液治疗牙龈炎疗效明显,能缓解临床症状,并能降低牙龈相关指数及炎性因子,值得临床借鉴及推广。
Objective To investigate the clinical study of Yiqing Capsules combined with Xipayi Guying Liquid in treatment of gingivitis.Methods A total of 118 gingivitis patients treated in the Department of Stomatology, Special Medical Center of the Chinese People’s Armed Police Force from April 2019 to April 2021 were selected and divided into control group and treatment group according to random number method, with 59 cases in each group. Patients in the control group were given Xipayi Guying Liquid, 5 mL/time, gargle for 2-3 min, 3 times daily. Patients in the treatment group were po administered with Yiqing Capsules on the basis of the control group, 2 capsules/time, 3 times daily. Patients in both groups continued to take drugs for 7 d. The clinical efficacy of the two groups were observed,and the improvement time of clinical symptoms, plaque index(PLI) score, gingival sulcus bleeding index(SBI) score, gingival index(GI)score, and inflammatory factors of gingival crevicular fluid were compared between the two groups. Results After treatment, the total effective rate in the treatment group was 98.31%, significantly higher than that in the control group(83.05%, P < 0.05). After treatment,the improvement time of gingival bleeding, gingival swelling, gingival pain, bad breath and other symptoms in the treatment group was significantly shorter than that in the control group(P < 0.05). After treatment, PLI, SBI and GI scores in two groups were significantly lower than before(P < 0.05). After treatment, the gingival correlation score in the treatment group was significantly lower than that in the control group(P < 0.05). After treatment, the levels of inflammatory factor interleukin-17(IL-17), soluble intercellular adhesion molecule 1(sicAM-1), tumor necrosis factor α(TNF-α) and C-reactive protein(CRP) in gingival crevicular fluid in two groups were significantly decreased(P < 0.05). After treatment, the level of gingival crevicular fluid inflammatory factors in the treatment group was significantly lower than that in the control group(P < 0.05). Conclusion Yiqing Capsules combined with Xipayi Guying Liquid has obvious curative effect in treatment of gingivitis, and can alleviate clinical characteristics, and can effectively reduce gingival correlation index and inflammatory factors, which is worthy of clinical reference and promotion.
作者
陈思果
何淼
邬礼政
CHEN Si-guo;HE Miao;WU Li-zheng(Department of Stomatology,Chinese People's Armed Police Force Characteristic Medical Center,Tianjin 300162,China)
出处
《现代药物与临床》
CAS
2021年第12期2578-2582,共5页
Drugs & Clinic
基金
天津市科委重点攻关项目(TCHA2017DH8735)。
