摘要
目的观察脑梗死患者应用丁苯酞联合阿托伐他汀钙治疗方式的临床效果,并探析对患者侧支循环的影响。方法研究对象为方便选取2020年1月—2021年7月该院收治的脑梗死患者(n=90),采用随机抛硬币方式按1∶1的比例分配,设定组名为对照组(n=45)与研究组(n=45),两组患者均于入院后进行常规治疗,在其基础上,对照组对患者开展的临床治疗方式为阿托伐他汀钙,研究组对患者开展的临床治疗方式为丁苯酞联合阿托伐他汀钙,对两组患者临床治疗前后侧支循环建立情况、血脂情况、神经功能以及生活能力予以比较,并对比两组患者不良反应发生情况。结果研究组患者大脑中动脉侧支循环血流速度、缺血区域脑流量、总胆固醇、三酰甘油、高低密度脂蛋白、Barthel指数、NIHSS评分分别为(33.84±3.93)cm/s、(27.14±3.48)mL/(100 g·min)、(3.92±0.34)mmol/L、(1.61±0.20)mmol/L、(1.49±0.16)mmol/L、(1.82±0.38)mmol/L、(60.46±4.27)分、(7.23±1.87)分,明显优于对照组,差异有统计学意义(t=15.967、4.053、4.741、4.621、2.298、5.040、13.212、12.389,P<0.001);同时,研究组患者不良反应发生率为2.2%,显著低于对照组,差异有统计学意义(χ^(2)=4.444,P=0.035)。结论应用丁苯酞联合阿托伐他汀钙方式对脑梗死患者进行治疗,可促进患者侧支循环建立,减轻患者神经功能损伤情况,值得在临床中大力推广。
Objective To observe the clinical effect of butylphthalide combined with atorvastatin calcium treatment in patients with cerebral infarction,and to explore the effect on the collateral circulation of patients.Methods The research objects conveniently selected patients with cerebral infarction(n=90)admitted to the hospital from January 2020 to July 2021.Random coin tossing was used to allocate at a ratio of 1:1.The set group was named the control group(n=45)and the study group(n=45).Patients in the two groups received conventional treatment after admission.On the basis of this,the clinical treatment of the control group was atorvastatin calcium,and the clinical treatment of the study group was butylphthalide combined with atorvastatin calcium to compare the establishment of collateral circulation,blood lipids,nerve function and living ability of the two groups of patients before and after clinical treatment,and to compare the occurrence of adverse reactions between the two groups.Results The middle cerebral artery collateral blood flow velocity,cerebral flow in the ischemic area,total cholesterol,triglycerides,high-low-density lipoprotein,Barthel index,and NIHSS scores of the patients in the study group were(33.84±3.93)cm/s,(27.14±3.48)mL/(100 g·min),(3.92±0.34)mmol/L,(1.61±0.20)mmol/L,(1.49±0.16)mmol/L,(1.82±0.38)mmol/L,(60.46±4.27)points,(7.23±1.87)points,significantly better than the control group,the difference was statistically significant(t=15.967,4.053,4.741,4.621,2.298,5.040,13.212,12.389,P<0.001);The incidence of adverse reactions in the study group was 2.2%,which was significantly lower than that in the control group,and the difference was statistically significant(χ^(2)=4.444,P=0.035).Conclusion The use of butylphthalide combined with atorvastatin calcium in the treatment of patients with cerebral infarction can promote the establishment of collateral circulation and reduce the patient's neurological damage.It is worthy of promotion in the clinic.
作者
温志鹏
林鹏星
WEN Zhipeng;LIN Pengxing(Department of Neurology,Affiliated Hospital of Putian University,Putian,Fujian Province,351100 China)
出处
《中外医疗》
2021年第32期113-116,共4页
China & Foreign Medical Treatment
关键词
丁苯酞
阿托伐他汀钙
脑梗死
侧支循环
生活能力
Butylphthalide
Atorvastatin calcium
Cerebral infarction
Collateral circulation
Living ability
