摘要
目的探讨温阳通络方对急性心肌梗死(AMI)经皮冠状动脉介入治疗(PCI)术后患者心室重构和血管内皮功能的影响。方法简单随机选取2019年1月—2021年1月在该院接受PCI治疗的AMI患者80例,以随机数表法分为对照组与观察组,各40例。对照组接受阿司匹林,氯吡格雷+阿托伐他汀治疗,观察组加用温阳通络方治疗,比较两组临床疗效及心室重构和血管内皮功能的变化。结果观察组治疗总有效率高于对照组(92.50%vs 75.00%),差异有统计学意义(χ^(2)=4.501,P=0.034);观察组治疗后胸闷、气短与心悸积分低于对照组,差异有统计学意义(P<0.05);观察组治疗后左室舒张末内径(LVEDD)小于对照组,左室射血分数(LVEF)与室间隔厚度(IVSd)大于对照组,差异有统计学意义(P<0.05);观察组治疗后血清基质金属蛋白酶-9(MMP-9)与肿瘤坏死因子-α(TNF-α)水平低于对照组,差异有统计学意义(P<0.05),一氧化氮(NO)水平高于对照组,差异有统计学意义(P<0.05)。结论温阳通络方可改善AMI患者接受PCI术后心室重构与血管内皮功能。
Objective To investigate the effect of Wenyang Tongluo Recipe on ventricular remodeling and vascular endothelial function in patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods 80 AMI patients who received PCI in the hospital from January 2019 to January 2021 were simple randomly selected and divided into a control group and an observation group,with 40 cases in each group,using a random number table method.The control group received aspirin+clopidogrel+atorvastatin,and the observation group was treated with Wenyang Tongluo Decoction on the basis of the observation group to compare the clinical efficacy and changes in ventricular remodeling and vascular endothelial function between the two groups.Results The total effective rate in the observation group was higher than that in the control group(92.50%vs 75.00%),and the difference was statistically significant(χ^(2)=4.501,P=0.034).The scores of chest tightness,shortness of breath and palpitation in the observation group were lower than those in the control group,the difference was statistically significant(P<0.05);the left ventricular end diastolic diameter(LVEDD)of the observation group was smaller than that of the control group,left ventricular ejection fraction(LVEF)and ventricular septal thickness(IVSd)were higher than those in the control group,and the differences were statistically significant(P<0.05);after treatment,the levels of matrix metalloproteinase-9(MMP-9)and tumor necrosis factor-α(TNF-α)in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05),the level of nitric oxide(NO)was significantly higher than that of control group,the difference was statistically significant(P<0.05).Conclusion Wenyang Tongluo Decoction can improve ventricular remodeling and vascular endothelial function in patients with AMI after PCI.
作者
乔建峰
熊尚全
吴翔
林超
QIAO Jianfeng;XIONG Shangquan;WU Xiang;LIN Chao(Department of Cardiology,the Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine,Fuzhou,Fujian Province,350004 China)
出处
《中外医疗》
2021年第34期187-190,共4页
China & Foreign Medical Treatment
关键词
急性心肌梗死
经皮冠状动脉介入术
温阳通络方
心室重构
血管内皮功能
临床疗效
Acute myocardial infarction
Percutaneous coronary intervention
Wenyang Tongluo prescription
Ventricular remodeling
Vascular endothelial function
Clinical efficacy
