摘要
【目的】探讨免疫组化指标及肿瘤标志物与胃癌临床病理特征的相关性。【方法】回顾性分析2015年12月至2019年12月于本院就诊的152例胃癌患者的临床资料,分析免疫组化中人类表皮生长因子受体(Her-2)、表皮生长因子受体(EGFR)及抗原ki67(Ki67)的表达及肿瘤标志物癌胚抗原(CEA)、糖链抗原(CA125)及糖链抗原(CA19-9)的水平与胃癌患者临床病理特征的相关性。【结果】Her-2、EGFR、Ki67表达与有淋巴转移、高分化及TNMⅢ、Ⅳ期之间存在相关性(P<0.05);有肿瘤淋巴转移患者CEA、CA125、CA19-9水平明显高于无转移患者(P<0.05),以肿瘤2.4 cm为界,肿瘤直径增大患者血清中CEA、CA125、CA19-9水平明显高于肿瘤直径较小者(P<0.05)。CA125水平随患者病理分化程度升高而降低(P<0.05);在胃癌患者中,Ⅱ期、Ⅲ期、Ⅳ期的CEA、CA125、CA199的表达高于I期(P<0.05),Ⅲ期、Ⅳ期的CEA、CA125、CA199的表达高于Ⅱ期(P<0.05),Ⅳ期的CEA、CA125、CA199的表达高于Ⅲ期(P<0.05)。【结论】免疫组化及肿瘤标志物能作为胃癌患者诊断的依据,为胃癌患者早期的诊断及治疗提供理论依据。
【Objective】To investigate the correlation of immunohistochemistry and tumor markers with clinicopathological characteristics of gastric cancer.【Methods】Retrospective analysis of all clinical data of 152 patients with gastric cancer treated in our hospital from December 2015 to December 2019 were studied.The relationship of the expression of human epidermal growth factor receptor(Her-2),epidermal growth factor receptor(EGFR),antigen ki67(Ki67),tumor markers carcinoembryonic antigen(CEA),sugar chain antigen(CA125 and CA19-9)with the clinicopathological characteristics of patients with gastric cancer.【Results】The expressions of HER-2,EGFR and Ki67 were correlated with lymphatic metastasis,high differentiation and TNM stagesⅢand IV(P<0.05).The levels of CEA,CA125 and CA19-9 in patients with tumor lymphatic metastasis were significantly higher than those in patients without metastasis(P<0.05).Taking the tumor diameter 2.4cm as the boundary,the levels of CEA,CA125 and CA19-9 in serum of patients with increased tumor diameter were significantly higher than those with smaller tumor diameter(P<0.05).The level of CA125 decreased with the increase of pathological differentiation(P<0.05).In patients with gastric cancer,the expression of CEA,CA125 and CA199 in stageⅡ,ⅢandⅣwas higher than that in stageⅠ(P<0.05),the expression of CEA,CA125 and CA199 in stageⅢandⅣwas higher than that in stageⅡ(P<0.05),and the expression of CEA,CA125 and CA199 in stageⅣwas higher than that in stageⅢ(P<0.05).【Conclusion】Immunohistochemistry and tumor markers can be used as useful reference for the diagnosis of gastric cancer patients,and provide a theoretical basis for the early diagnosis and treatment of gastric cancer patients.
作者
李继斌
王瑞
汤水平
LI Ji-bin;WANG Rui;TANG Shui-ping(Department of Pathology,Shenmu City Hospital,Shenmu 719300)
出处
《医学临床研究》
CAS
2021年第12期1860-1863,共4页
Journal of Clinical Research
基金
陕西省重点研发计划项目(2018YBXM-SF-12-1)。
