摘要
目的分析溶血卵磷脂胆碱酰基转移酶1(LPCAT1)与非小细胞肺癌(NSCLC)患者临床特征及预后的关系。方法收集95例NSCLC患者癌旁组织及肿瘤组织,采用实时定量逆转录聚合酶链反应(qRT-PCR)法对其癌旁组织及肿瘤组织中的LPCAT1 mRNA相对表达量进行比较,分析LPCAT1 mRNA相对表达量与NSCLC患者临床特征及预后的关系。结果NSCLC患者癌旁组织LPCAT1 mRNA相对表达量为(0.069±0.017),明显低于肿瘤组织的(0.621±0.124),差异有统计学意义(P﹤0.01)。TNM分期为Ⅲ期、有淋巴结转移的NSCLC患者肿瘤组织中LPCAT1 mRNA相对表达量均明显高于TNM分期为Ⅰ~Ⅱ期、无淋巴结转移者(P﹤0.01);不同年龄、性别、病理类型、肿瘤直径、分化程度及是否吸烟NSCLC患者的肿瘤组织中LPCAT1 mRNA相对表达量比较,差异均无统计学意义(P﹥0.05)。LPCAT1 mRNA相对表达量高水平组患者总生存率为37.50%,低于低水平组的68.09%,差异有统计学意义(P﹤0.05)。结论NSCLC患者肿瘤组织中LPCAT1 mRNA相对表达量高于癌旁组织,且NSCLC患者临床特征及预后与LPCAT1 mRNA相对表达量有关。
Objective To analyze the relationship between lysophosphatidylcholine acyltransferase 1(LPCAT1)and clinical characteristics and prognosis of patients with non-small cell lung cancer(NSCLC).Method A total of 95 cases with NSCLC patients’adjacent tissues and tumor tissues were collected,the relative expression of LPCAT1 mRNA in their adjacent tissues and tumor tissues were compared using quantitative reverse transcription-polymerase chain reaction(qRT-PCR).The relationship between the relative expression of LPCAT1 mRNA and the clinical characteristics and prognosis of NSCLC patients was also analyzed.Result The relative expression of LPCAT1 mRNA in adjacent tissues of NSCLC patients was(0.069±0.017),significantly lower than that of the tumor tissues with(0.621±0.124),the difference was statistically significant(P<0.01).The relative expression of LPCAT1 mRNA in the tumor tissues of NSCLC patients with TNM stage Ⅲ and lymph node metastasis were significantly higher than those of TNM stage Ⅰ to Ⅱ and without lymph node metastasis(P<0.01).There were no significant differences in the relative expression of LPCAT1 mRNA in NSCLC patients with different ages,genders,pathological types,tumor diameter,differentiation grade,and whether smoking or not(P>0.05).The overall survival of patients in the LPCAT1 mRNA up-regulation group was 37.50%,lower than 68.09%of the down-regulation group,the difference was statistically significant(P<0.05).Conclusion The relative expression of LPCAT1 mRNA in tumor tissues of NSCLC patients are higher than their adjacent tissues,the clinical characteristics and prognosis of NSCLC patients are related to the relative expression of LPCAT1 mRNA.
作者
杨昕
刘芳
张继朋
YANG Xin;LIU Fang;ZHANG Jipeng(Department of Pathology,the Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Xi’an 712000,Shaanxi,China;Department of Thoracic Surgery,Tangdu Hospital,Air Force Military Medical University,Xi’an 710038,Shaanxi,China)
出处
《癌症进展》
2021年第23期2417-2419,2465,共4页
Oncology Progress
关键词
非小细胞肺癌
溶血卵磷脂胆碱酰基转移酶1
临床特征
non-small cell lung cancer
lysophosphatidylcholine acyltransferase 1
clinical characteristic
