摘要
目的:探讨Oct4与EGFR在右半结肠癌组织中表达的相关性及临床价值。方法:应用免疫组织化学法检测120例右半结肠癌组织中Oct4与EGFR的表达,并与病理参数进行相关性分析;结合GEPIA数据库结果确认两者相关性。结果:免疫组化染色结果显示,Oct4表达与组织学分级、淋巴结转移以及TNM分期呈正相关(P<0.05),EGFR与肿瘤直径大小、组织学分级以及TNM分期呈正相关(P<0.01)。根据免疫组化评分结果可见,Oct4阳性表达中,EGFR阳性表达率为50.0%(26/52),Oct4阴性表达中,EGFR阳性表达率仅为29.41%(20/68),结合GEPIA数据库分析确认Oct4与EGFR表达呈正相关。另外,Oct4与EGFR双阳性者26例,与肿瘤直径大小、组织学分级、淋巴结转移以及TNM分期呈正相关(P<0.05)。结论:Oct4和EGFR在右半结肠癌组织中的表达呈正相关,两者联合检测能够弥补临床病理学诊断的缺陷,为探索右半结肠癌靶向治疗提供新的理论依据。
Objective:To investigate the correlation and clinical value of Oct4 and EGFR in right-sided colon cancer.Methods:Expressions of Oct4 and EGFR in 120 cases of right-sided colon cancer were detected by immunohistochemistry and the relationship of pathological parameters were analyzed.The correlation between Oct4 and EGFR was confirmed through immunohistochemistry and the GEPIA database.Results:Immunohistochemical staining showed that Oct4 expression was positively correlated with histological grade,lymph node metastasis and TNM stage(P<0.05),while EGFR was positively correlated with tumor diameter,histological grade and TNM stage(P<0.01).According to the immunohistochemical score,the EGFR positive expression rate was 50.0%(26/52)in the positive expression of Oct4,while the EGFR positive expression rate was only 29.41%(20/68)in the negative expression of Oct4.Combined with the analysis of the GEPIA database,it was confirmed that Oct4 was positively correlated with EGFR.In addition,26 cases both with Oct4 and EGFR positive in were positively correlated with tumor diameter,histological grade,lymph node metastasis and TNM stage(P<0.05).Conclusion:There is a positive correlation between Oct4 and EGFR in the right-side colon cancer.The combined detection of Oct4 and EGFR could make up the deficiency of clinical pathology diagnosis and provide a new theoretical basis for the exploration of targeted therapy for the right-side colon cancer.
作者
程杰
史春桃
陈超波
韩玮
王庆华
CHENG Jie;SHI Chuntao;CHEN Chaobo;HAN Wei;WANG Qinghua(Department of General Surgery,Wuxi Xishan People's Hospital,Jiangsu Wuxi 214000,China;Department of General Surgery,Kunshan Hospital Affiliated to Jiangsu University,Jiangsu Kunshan 215300,China;Gastroenterology Department,Kunshan Hospital Affiliated to Jiangsu University,Jiangsu Kunshan 215300,China)
出处
《现代肿瘤医学》
CAS
北大核心
2022年第1期94-97,共4页
Journal of Modern Oncology
