摘要
目的 探讨分析环孢素在子痫前期高风险孕妇中的应用效果。方法 选择2019年9月至2020年10月我院收治的60例子痫前期高风险孕妇,随机分成对照组(n=30)和观察组(n=30)。对照组口服阿司匹林治疗,观察组在对照组基础上口服环孢素治疗,两组均治疗至孕28周。统计两组孕妇的子痫前期发生情况、肝肾功能及炎性因子水平。结果 观察组子痫前期发生率为6.67%,明显低于对照组的30.00%(P<0.05)。产后2周,两组的Scr、 BUN、 ALT、 AST、 IL-6、 TNF-α水平均低于治疗前,且观察组的Scr、 BUN、 ALT、 AST、 IL-6、 TNF-α水平明显低于对照组(P<0.05)。结论 环孢素可明显降低子痫前期高风险孕妇的子痫前期发生率,减轻其肝肾功能损伤及炎性反应。
Objective To explore and analyze the application effect of cyclosporine in pregnant women with high risk of preeclampsia.Methods 60 pregnant women with high risk of preeclampsia admitted to our hospital from September 2019 to October 2020 were selected and randomly divided into control group(n=30)and observation group(n=30).The control group was treated with oral aspirin,and the observation group was treated with oral cyclosporine based on the control group.Both groups were treated until 28 weeks of pregnancy.The incidence of preeclampsia,liver and renal function,and levels of inflammatory factors were compared between the two groups.Results The incidence of preeclampsia in the observation group was 6.67%,significantly lower than 30.00%in the control group(P<0.05).2 weeks after delivery,the Scr,BUN,ALT,AST,IL-6 and TNF-αlevels of the two groups were lower than those before treatment,and the Scr,BUN,ALT,AST,IL-6 and TNF-αlevels of the observation group were significantly lower than those of the control group(P<0.05).Conclusions Cyclosporine can significantly reduce the incidence of preeclampsia,relieve the liver and renal function damage and inflammatory reactions in pregnant women with high risk of preeclampsia.
作者
卢涛
张琰
齐琳
邢宇瑞
郭华娟
LU Tao;ZHANG Yan;QI Lin;XING Yurui;GUO Huajuan(Department of Obstetrics and Gynecology,Kaifeng Maternal and Child Healthcare Hospital,Kaifeng 475002,China;Kaifeng Key Laboratory of Reproductive Endocrinology,Kaifeng Maternal and Child Healthcare Hospital,Kaifeng 475002,China)
出处
《临床医学工程》
2022年第1期49-50,共2页
Clinical Medicine & Engineering
基金
2019年度开封市科技发展计划项目“环孢素降低炎性因子改善子痫前期高危人群的疗效观察”(项目编号:2003113)。
关键词
子痫前期
环孢素
肝功能
肾功能
炎性反应
Preeclampsia
Cyclosporine
Liver function
Renal function
Inflammatory reaction
