摘要
目的系统评价2型糖尿病与肾癌发生的相关性。方法计算机检索PubMed、EMbase、Web of Science、CBM、VIP和CNKI数据库,搜集有关2型糖尿病和肾癌发生相关性的队列研究,检索时限均从建库至2021年8月。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Stata 15.0软件进行Meta分析。结果共纳入17个队列研究,包括2型糖尿病患者2003165例。Meta分析结果显示,2型糖尿病患者的肾癌发生风险明显高于对照组[RR=1.51,95%CI(1.39,1.64),P<0.001]。亚组分析结果显示:不同性别、地域、人群、随访时间、糖尿病评估方法等2型糖尿病患者肾癌的发生率均更高。结论当前证据显示,2型糖尿病可能是肾癌发生的危险因素。
Objective To systematically review the correlation between type 2 diabetes mellitus(T2DM)and the risk of kidney cancer.Methods PubMed,EMbase,Web of Science,CBM,VIP and CNKI databases were electronically searched to collect cohort studies on the association between T2DM and kidney cancer from inception to August 2021.Two reviewers independently screened literature,extracted data and assessed the risk of bias of the included studies.Metaanalysis then performed by using Stata 15.0 software.Results A total of 17 cohort studies involving 2003165 T2DM patients were included.The results of meta-analysis showed that patients with T2DM had a higher kidney cancer risk than controls(RR=1.51,95%CI 1.39 to 1.64,P<0.001).Subgroup analysis showed that the incidence of kidney cancer in T2DM patients was higher in different gender,region,population,follow-up time,diabetes assessment method and other subgroups.Conclusions Current evidence shows that T2DM is a risk factor for kidney cancer.
作者
朱梦薇
付书磊
全贞玉
ZHU Mengwei;FU Shulei;QUAN Zhenyu(Medical College of Yanbian University,Yanji 133002,P.R.China)
出处
《中国循证医学杂志》
CSCD
北大核心
2022年第1期73-78,共6页
Chinese Journal of Evidence-based Medicine
基金
国家自然科学基金项目(编号:816660562)。
关键词
2型糖尿病
肾癌
队列研究
META分析
系统评价
Type 2 diabetes mellitus
Kidney cancer
Cohort study
Meta-analysis
Systematic review
