摘要
目的:探讨奥氮平联合碳酸锂治疗对于难治性精神分裂症患者的意义。方法:纳入2020年1月—2021年1月江西康宁医院接诊的难治性精神分裂症患者60例,按照随机数字表对照法分为两组,每组30例。对照组给予奥氮平治疗,首次剂量10 mg/次,1次/d,3~10 d后增加至20 mg/次,1次/d。观察组在对照组基础上联合碳酸锂治疗,0.5 g/次,1次/d,3~10 d后增加至1 g/次,1次/d。两组均连续治疗3个月。比较两组患者治疗前后阳性和阴性症状量表(positive and negative symptom scale,PANSS)评分、简易精神状态评价量表(mini mental state evaluation scale,MMSE)评分及护士用住院患者护理观察量表(nurse’s observation scale for inpatient evaluation,NOSIE)评分变化情况。结果:两组治疗后PANSS评分均低于同组治疗前(P<0.05),且观察组低于对照组(P<0.05);而MMSE评分则高于同组治疗前(P<0.05),且观察组高于对照组(P<0.05)。两组治疗后精神病性、激怒评分均低于同组治疗前(P<0.05),且观察组低于对照组(P<0.05);个人整洁、社会兴趣、社会能力均高于同组治疗前(P<0.05),且观察组均高于对照组(P<0.05)。结论:奥氮平联合碳酸锂方案能够有效改善难治性精神分裂症患者的病情,促进认知功能恢复和生活质量提高,值得临床推荐。
Objective:To explore the significance of olanzapine combined with lithium carbonate in the treatment of patients with refractory schizophrenia.Methods:Sixty patients with refractory schizophrenia treated in Kangning Hospital,Jiangxi from January 2020 to January 2021 were included as the research objects,and according to the random number table control method,divided into two groups with 30 cases each.The control group was treated with olanzapine,and the first dose was 10 mg/time,once/d,and increased to 20 mg/time,once/d after 3-10 days,and the observation group was combined with lithium carbonate treatment on the basis of the control group,0.5 g/time,1 time/d,and increased to 1 g/time,1 time/d after 3-10 days.Both groups were treated continuously for 3 months.The positive and negative symptom scale(PANSS)scores,the mini mental state evaluation scale(MMSE)scores and nurse’s observation scale for inpatient evaluation(NOSIE)score changes were compared between the two groups before and after treatment.Results:The PANSS scores of the two groups after treatment were lower than those of the same group before treatment(P<0.05),and the observation group was lower than the control group(P<0.05);after treatment the MMSE score was higher than the same group before treatment(P<0.05),and the observation group was higher than the control group(P<0.05).The scores of psychosis and irritation after treatment in the two groups were lower than those before treatment in the same group(P<0.05),and the observation group was lower than the control group(P<0.05);personal cleanliness,social interest and social ability were higher than those in the same group before treatment(P<0.05),and the observation group was higher than the control group(P<0.05).Conclusion:Olanzapine combined with lithium carbonate can effectively improve the condition of patients with refractory schizophrenia,promote the recovery of cognitive function and improve the quality of life,which is worthy of clinical recommendation.
作者
陈江
CHEN Jiang(Psychiatry Department of Kangning Hospital,Jiangxi Province 331211,China)
出处
《上海医药》
CAS
2022年第2期32-34,共3页
Shanghai Medical & Pharmaceutical Journal
关键词
难治性精神分裂症
奥氮平
碳酸锂
认知功能
生活质量
refractory schizophrenia
olanzapine
lithium carbonate
cognitive function
quality of life
