摘要
目的采用差示扫描量热法(differential scanning calorimetry,DSC)测定磺胺类化学对照品纯度。方法采用优化DSC实验参数,载气流速50 mL·min^(–1),升温速率3℃·min^(-1),称样量1.3~2.0 mg,对7种磺胺类化学对照品进行纯度分析。结果DSC测得磺胺噻唑纯度为99.9%,磺胺甲二唑为99.9%,磺胺甲氧嗪为99.8%,磺胺嘧啶为99.8%,磺胺甲噁唑为99.9%,磺胺多辛为99.5%和磺胺二甲嘧啶为99.9%,其结果与质量平衡法测定结果基本一致。结论DSC简便、快捷、无需标准物质,为磺胺类化学对照品纯度测定提供了新的检测方法。
OBJECTIVE To determine the purity of sulfonamide chemical reference substances by differential scanning calorimetry(DSC).METHODS The purity of 7 sulfonamide chemical reference substances was determined by optimizing DSC parameters,carrier gas flow rate was 50 mL·min^(-1),heating rate was 3℃·min^(-1) and weighing amount was 1.3−2.0 mg.RESULTS The purity determined by DSC were 99.9%(sulfathiazole),99.9%(sulfamethizole),99.8%(sulfamethoxypridazine),99.8%(sulfadiazine),99.9%(sulfamethoxazole),99.7%(sulfadoxine),and 99.9%(sulfadimidine),respectively.The results of purity determination by DSC method were basically consistent with those by mass balance method.CONCLUSION DSC is a simple,rapid method,and does not need standard substance.It provides a new method for the purity determination of sulfonamide chemical reference substances.
作者
张雅军
吴先富
肖新月
ZHANG Yajun;WU Xianfu;XIAO Xinyue(National Institutes for Food and Drug Control,Beijing 102629,China)
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2022年第1期93-96,共4页
Chinese Journal of Modern Applied Pharmacy
关键词
差示扫描量热法
磺胺类
化学对照品
differential scanning calorimetry
sulfonamides
chemical reference substances
