摘要
目的探讨蒙药乌日特-3联合西替利嗪治疗过敏性鼻炎急性发作期的临床疗效。方法选取2020年7-8月内蒙古锡林郭勒盟蒙医医院门诊接诊的过敏性鼻炎患者共78例,按照随机数字表法分为对照组和联合组,每组39例。对照组给予盐酸西替利嗪片口服治疗,联合组在对照组的基础上增加乌日特-3(含家黑种草3 g、甘草1 g、小茴香1 g)口服治疗。两组均连续治疗15 d,观察临床疗效,比较两组患者治疗前后临床症状评分、血液生化指标、尿蛋白、尿隐血、心率、心电图、胸部X片异常情况,以及过敏原点刺试验结果。结果治疗后,联合组显效率(76.92%)高于对照组(20.51%),差异有统计学意义(P<0.05);治疗后,两组患者临床症状评分和总分均显著低于治疗前(P<0.05),并且治疗后联合组鼻塞和总分均显著低于对照组(P<0.05);两组患者治疗前后血液生化指标、尿蛋白、尿隐血、心率、心电图、胸部X片异常情况比较,差异均无统计学意义(P>0.05);治疗后,联合组患者对17种过敏原中的15种过敏性较治疗前降低(P<0.05),且联合组与对照组过敏原点刺试验结果比较,差异无统计学意义(P>0.05)。结论蒙药乌日特-3联合西替利嗪治疗急性发作期过敏性鼻炎具有较好的临床疗效,可明显改善患者临床症状,且对肝、肾功能无明显影响,具有一定的临床推广价值。
Objective To investigate the clinical efficacy of Mongolian medicine Wurite-3 combined with cetirizine in the treatment of acute attack of allergic rhinitis.Methods A total of 78 patients with allergic rhinitis in the Outpatient Department of Xilin Gol League Mongolian Medical Hospital from July to August 2020 were selected and divided into control group and combined group according to random number table method,with 39 patients in each group.The control group was treated with cetirizine hydrochloride tablets while the combined group was additionally treated with Wurite-3(containing 3 g of Nigella sativa,1 g of Licorice and 1 g of Foeniculi Frucus)on the basis of control group.Both groups were treated for 15 days,and the clinical efficacy was observed.The clinical symptom scores,blood biochemical indexes,urinary protein,urinary occult blood,heart rate,electrocardiogram(ECG),chest X-ray abnormalities and allergen prick test results were compared between the two groups before and after treatment.Results After treatment,the effective rate of the combined group(76.92%)was higher than that of the control group(20.51%),and the difference was statistically significant(P<0.05).After treatment,the clinical symptom scores and total scores of the two groups were significantly lower than those before treatment(P<0.05),and nasal obstruction and total scores of combined group were significantly lower than those of the control group(P<0.05).There was no significant difference in blood biochemical indexes,urinary protein,octonal blood,heart rate,ECG and chest X-ray abnormalities between the two groups before and after treatment(P>0.05).After treatment,the allergy of combined group to 15 out of 17 allergens was significantly decreased(P<0.05).There was no significant difference in allergen prick test results between the combined group and the control group(P>0.05).Conclusion Mongolian medicine Wurite-3 combined with cetirizine has good clinical in the treatment of acute attack allergic rhinitis,which can significantly improve the clinical symptoms of patients,and has no significant effect on liver and kidney function,so it has certain clinical promotion value.
作者
廖成松
白松林
乌兰其其格
敖德毕力格
贡斯琴
韩阳阳
莲花
小华
陈志婧
包勒尔
斯琴图
温永顺
阿拉坦沙
魏其其格
金仓
乌尼尔
马强
LIAO Chengsong;BAI Songlin;Wulanqiqige;Odebilige;GONG Siqin;HAN Yangyang;Lianhua;Xiaohua;CHEN Zhijing;Baoler;Siqintu;WEN Yongshun;Alatansha;WEI Qiqige;Jincang;Wunier;MA Qiang(Xilin Gol Bioengineering Research Institute,Xilin Gol Vocational College,Xilinhot,Inner Mongolia 026000,China;Outpatient Department,Xilin Gol League Mongolian Medical Hospital,Xilinhot,Inner Mongolia 026000,China;Inner Mongolia Medical University,Hohhot,Inner Mongolia 010110,China)
出处
《检验医学与临床》
CAS
2022年第3期292-296,共5页
Laboratory Medicine and Clinic
基金
内蒙古自治区锡林郭勒盟科技计划项目(201806)。
关键词
蒙药
乌日特-3
西替利嗪
过敏性鼻炎
临床疗效
Mongolian medicine
Wurite-3
cetirizine
allergic rhinitis
clinical effects
