摘要
目的分析冠心病患者血栓前状态分子、血清补体C1q/肿瘤坏死因子相关蛋白1(CTRP1)水平与经皮冠状动脉介入(PCI)术后预后的关系。方法选取2019年6月至2020年8月在西安市北方医院行PCI术的冠心病患者112例,检测其手术前后血栓前状态分子[血清血管性血友病因子(vWF)、血浆纤维蛋白原(FIB)、D二聚体(D-D)、血栓前体蛋白(TpP)]、血清CTRP1水平,术后随访6个月,根据主要心血管不良事件(MACE)情况,分为MACE组与无MACE组,采用Logistic多因素分析MACE发生的危险因素。结果冠心病患者PCI术后3 d血清CTRP1、vWF、FIB、D-D、TpP水平较术前明显升高(P<0.05);MACE组与无MACE组性别、年龄、体质量指数(BMI)、高脂血症患者占比及血脂水平比较,差异均无统计学意义(P>0.05);MACE组与无MACE组糖尿病、高血压情况及术后血清CTRP1、vWF、FIB、D-D、TpP水平升高程度比较,差异有统计学意义(P<0.05);多因素Logistic回归分析显示,糖尿病、高血压及术后血清CTRP1、vWF、FIB、D-D、TpP升高属于冠心病患者预后独立危险因素(P<0.05)。结论冠心病患者PCI术后血清CTRP1与血栓前状态分子呈升高趋势,二者均属于预后独立危险因素,升高程度越大,MACE发生风险越高。
Objective To analyze the relationship between prethrombotic state molecules,serum C1q complement/tumor necrosis factor-related protein(CTRP1)levels and the prognosis of percutaneous coronary intervention(PCI)in patients with coronary heart disease.Methods A total of 112 patients with coronary heart disease who underwent PCI in Xi′an North Hospital from June 2019 to August 2020 were selected to detect the levels of pre-thrombotic state molecules[serum von Willebrand factor(vWF),plasma fibrinogen(FIB),D-dimer(D-D),thrombotic precursor protein(TpP)]and serum CTRP1 before and after surgery.All patients were followed up for 6 months after surgery.According to the occurrence of major adverse cardiovascular events(MACE),the patients were divided into MACE group and non-MACE group,and multivariate Logistic analysis was performed to analyze the risk factors.Results The levels of CTRP1,vWF,FIB,D-D and TpP in patients with coronary heart disease were significantly increased 3 days after PCI operation compared with those before operation(P<0.05).There were no significant differences in gender,age,BMI,proportion of patients with hyperlipidemia and lipid levels between MACE group and non-MACE group(P>0.05).However,there were statistically significant differences between MACE group and non-MACE group in diabetes and hypertension as well as the elevated levels of postoperative serum CTRP1,vWF,FIB,D-D and TpP(P<0.05).Multivariate Logistic analysis showed that diabetes mellitus,hypertension,postoperative elevated levels of CTRP1,vWF,FIB,D-D and TpP were independent prognostic risk factors in patients with coronary heart disease(P<0.05).Conclusion Serum CTRP1 and prethrombotic state molecules in patients with coronary heart disease show an increasing trend after PCI,which are independent risk factors for prognosis.The greater the increase,the higher the risk of MACE.
作者
张院
任小慧
李红梅
余伦伦
ZHANG Yuan;REN Xiaohui;LI Hongmei;YU Lunlun(First Department of Cardiology,Xi′an North Hospital,Xi′an,Shaanxi 710043,China;Department of Geriatrics,the Fourth People′s Hospital of Shaanxi,Xi′an,Shaanxi 710043,China)
出处
《检验医学与临床》
CAS
2022年第3期350-353,共4页
Laboratory Medicine and Clinic
关键词
冠心病
经皮冠状动脉介入术
血栓前状态分子
补体C1q/肿瘤坏死因子相关蛋白1
coronary heart disease
percutaneous coronary intervention
prethrombotic state molecule
C1q complement/tumor necrosis factor related protein 1
