摘要
目的探索卷曲霉素联合左氧氟沙星治疗复治痰涂片检查阳性(涂阳)肺结核病的临床疗效。方法87例复治涂阳肺结核病患者,随机分为对照组(43例)与实验组(44例)。对照组单纯使用抗结核药物治疗,实验组在对照组基础上使用左氧氟沙星联合卷曲霉素治疗。对比两组临床疗效、不同时间涂阳转阴率、治疗12个月后免疫细胞水平。结果实验组的治疗总有效率为93.18%,高于对照组的65.12%,差异有统计学意义(P<0.05)。实验组治疗3、6、9、12个月的涂阳转阴率均高于对照组,差异均有统计学意义(P<0.05)。实验组治疗12个月后的CD3^(+)(1492.62±163.52)/μl、CD4^(+)(693.54±98.21)/μl高于对照组的(996.32±125.64)/μl、(579.14±95.27)/μl,CD8^(+)(395.24±44.65)/μl低于对照组的(498.01±45.74)/μl,差异有统计学意义(P<0.05)。两组CD4^(+)/CD8^(+)对比差异无统计学意义(P>0.05)。结论采用左氧氟沙星联合卷曲霉素方案治疗复治涂阳肺结核病效果确切,在涂阳阴转率及免疫细胞水平情况等方面有明显的优势。
Objective To investigate the clinical efficacy of capreomycin combined with levofloxacin in the treatment of retreated smear-positive pulmonary tuberculosis.Methods A total of 87 cases of retreated smear-positive pulmonary tuberculosis patients were randomly divided into control group(43 cases)and experimental group(44 cases).The control group was treated with anti-tuberculosis drugs alone,and the experimental group was treated with levofloxacin in combination with capreomycin on the basis of the control group.The clinical efficacy,smear-positive conversion rate at different time points,and immune cell level after 12 months of treatment were compared between the two groups.Results The total effective rate of treatment in the experimental group was 93.18%,which was higher than 65.12% in the control group,and the difference was statistically significant(P<0.05).The smear-positive conversion rates in the experimental group after 3,6,9 and 12 months of treatment were higher than those of the control group,and the differences were statistically significant(P<0.05).After 12 months of treatment,the CD3^(+)(1492.62±163.52)/μl and CD4^(+)(693.54±98.21)/μl of the experimental group were higher than(996.32±125.64)/μl and(579.14±95.27)/μl of the control group,and the CD8^(+)(395.24±44.65)/μl was lower than(498.01±45.74)/μl of the control group.All the difference was statistically significant(P<0.05).There was no statistically significant difference in CD4^(+)/CD8^(+)between the two groups(P>0.05).Conclusion Levofloxacin combined with capreomycin is effective in the treatment of retreated smear-positive pulmonary tuberculosis.It has obvious advantages in smear-positive conversion rate and immune cell level.
作者
田茜
TIAN Qian(Shenyang Chest Hospital,Shenyang 110044,China)
出处
《中国现代药物应用》
2022年第2期135-137,共3页
Chinese Journal of Modern Drug Application
关键词
复治涂阳肺结核病
左氧氟沙星
卷曲霉素
Retreated smear-positive pulmonary tuberculosis
Levofloxacin
Capreomycin
