摘要
目的探讨江苏省北部、安徽省南部地区子宫颈癌患者人乳头瘤病毒(HPV)感染和基因型分布特征,为子宫颈癌预防和HPV疫苗接种提供依据。方法回顾性分析江苏省徐州市肿瘤医院和江苏省肿瘤医院2016年7月至2019年6月收治的505例子宫颈癌患者的临床资料,患者主要来自江苏省北部及安徽省南部地区,其中41~60岁患者347例(68.7%)。分析患者HPV感染情况和基因型分布特点。结果505例患者中HPV总感染率96.6%(488/505),其中41~60岁患者占68.4%(334/488);单一感染率高于多重感染率[69.7%(352/505)比26.9%(136/505)]。不同临床分期患者HPV总感染率差异有统计学意义(χ^(2)=14.258,P<0.05),但感染率不随分期增加而上升。488例HPV阳性患者中,单一感染占72.1%(352/488),二重感染占17.4%(85/488),三重感染占6.2%(30/488),三重以上感染占4.3%(21/488)。352例HPV单一感染患者中,低危型感染占8.0%(28/352),高危型感染占92.1%(324/352),其中前3位感染高危HPV基因型分别为16、52和58型,共174例。136例HPV多重感染患者中,115例(84.6%)感染16、52、58型中的至少1种,其中16型合并其他型别感染者占53.7%(73/136)。结论江苏省北部及安徽省南部地区子宫颈癌患者高危HPV基因型感染率高,以16型最常见,这些地区接种九价疫苗预防子宫颈癌更有价值;41~60岁是HPV感染和子宫颈癌高发年龄,应加强防控。
Objective To investigate the characteristics of human papillomavirus(HPV)infection and genotype distribution among cervical cancer patients in northern Jiangsu Province and southern Anhui Province,so as to provide references for cervical cancer prevention and HPV vaccination.Methods The clinical data of 505 cervical cancer patients who were admitted to Xuzhou Cancer Hospital of Jiangsu Province and Jiangsu Cancer Hospital from July 2016 to June 2019 were retrospectively analyzed.The patients were mainly from northern Jiangsu Province and southern Anhui Province,and among them,347 patients(68.7%)were 41-60 years old.The patient's HPV infection and genotype distribution characteristics were analyzed.Results The total infection rate of HPV among 505 patients was 96.6%(488/505),of which patients aged 41-60 years old accounted for 68.4%(334/488);the single infection rate was higher than the multiple infection rate[69.7%(352/505)vs.26.9%(136/505)].There was a statistical difference in the total HPV infection rate of patients with different clinical stage(χ^(2)=14.528,P<0.05),but the infection rate did not increase with the increase of stage.Among 488 HPV-positive patients,single infection accounted for 72.1%(352/488),double infection accounted for 17.4%(85/488),triple infection accounted for 6.2%(30/488),and more than triple infection accounted for 4.3%(21/488).Among 352 patients with HPV single infection,low-risk type infection accounted for 8.0%(28/352),and high-risk type infection accounted for 92.1%(324/352).The top three high-risk HPV genotypes were type 16,type 52 and type 58,and there were 174 cases in total.Among 136 patients with multiple HPV infections,115 cases(84.6%)were infected with at least one of type 16,type 52 and type 58.Among them,the infection of type 16 combined with other types accounted for 53.7%(73/136).Conclusions The infection rates of high-risk HPV genotypes among cervical cancer patients in northern Jiangsu Province and southern Anhui Province are high,and type 16 is the most common.It is more valuable to inoculate the nine-valent vaccine to prevent cervical cancer in these areas;41-60 years old is the age at which HPV infection and cervical cancer are highly prevalent,so the prevention and control should be strengthened.
作者
王岚
王金华
张杰
刘蓓蓓
余晓娟
朱彦玲
Wang Lan;Wang Jinhua;Zhang Jie;Liu Beibei;Yu Xiaojuan;Zhu Yanling(Department of Gynecology and Oncology,Xuzhou Cancer Hospital of Jiangsu Province,Xuzhou Hospital Affiliated to Jiangsu University,Xuzhou Third People's Hospital,Xuzhou 221000,China;Department of Gynecology and Oncology,Jiangsu Cancer Hospital,Nanjing 210003,China)
出处
《肿瘤研究与临床》
CAS
2021年第12期933-937,共5页
Cancer Research and Clinic
关键词
宫颈肿瘤
人乳头瘤病毒
基因型
多重感染
Cervical neoplasms
Human papilloma virus
Genotype
Multiple infections
