摘要
目的探究普拉洛芬联合玻璃酸钠滴眼液治疗白内障超声乳化术后干眼患者的有效性。方法选取2018年1月至2019年12月本院收治的68例白内障超声乳化术后干眼患者作为研究对象,按照随机数字法分为观察组与对照组,各34例。对照组应用玻璃酸钠滴眼液治疗,观察组在对照组基础上联合普拉洛芬滴眼液治疗,比较两组临床疗效、干眼症状评分、泪膜破裂时间、角膜荧光素染色评分及Schirmer试验。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组干眼症状评分比较差异无统计学意义;治疗1、2、4周后,两组干眼症状评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组泪膜破裂时间、角膜荧光素染色评分、Schirmer试验比较差异无统计学意义;治疗后,两组泪膜破裂时间、角膜荧光素染色评分、Schirmer试验均优于治疗前,且观察组优于对照组,差异有统计学意义(P<0.05)。两组治疗期间均未发生明显不良反应。结论普拉洛芬联合玻璃酸钠滴眼液治疗白内障超声乳化术后干眼疗效显著,可明显降低患者的干眼症状评分,值得临床推广应用。
Objective To explore the effectiveness of pranoprofen combined with sodium hyaluronate eye drops in the treatment of dry eye patients after cataract phacoemulsification. Methods 68 patients with dry eye after phacoemulsification in our hospital from January 2018 to December 2019 were selected as the research subjects, and they were divided into observation group and control group according to random number method, with 34 cases in each group. The control group was treated with sodium hyaluronate eye drops alone, and the observation group was treated with pranoprofen eye drops on the basis of the control group. The clinical efficacy, dry eye symptom score, tear film rupture time, corneal fluorescein staining score and Schirmer test were compared between the two groups. Results Before treatment, the total effective rate of the observation group was higher than that of the control group(P<0.05). Before treatment, there was no significant difference in dry eye symptom scores between the two groups;after 1, 2 and 4 weeks of treatment, the dry eye symptom scores of the two groups were lower than those before treatment, and the observation group was lower than that of the control group, the difference was statistically significant(P<0.05). Before treatment, there was no significant difference in tear film rupture time, corneal fluorescein staining score and Schirmer test between the two groups;after treatment, the tear film breakup time, corneal fluorescein staining score, and Schirmer test after treatment in the two groups were better than before treatment, the observation group were better than those of the control group, the difference was statistically significant(P<0.05). During the treatment period of the two groups,no obvious adverse reactions occurred. Conclusion Praprofen combined with sodium hyaluronate eye drops in the treatment of dry eyes after cataract phacoemulsification has significant clinical effect and significantly improves the symptom score of dry eyes. It is worthy of clinical application.
作者
曾祥红
涂志英
江珊
ZENG Xianghong;TU Zhiying;JIANG shan(Department of Ophthalmology,Hong'an Aier Eye Hospital,Huanggang,Hubei,438400;Hong'an County Maternal and Child Health Hospital,Huanggang,Hubei,438400,China)
出处
《当代医学》
2022年第4期41-43,共3页
Contemporary Medicine
关键词
白内障
超声乳化术
干眼
普拉洛芬滴眼液
玻璃酸钠滴眼液
Cataract
Phacoemulsification
Dry eye
Pranoprofen eye drops
Sodium hyaluronate eye drops
