摘要
[背景]甲状腺癌严重威胁上海市居民的健康,是肿瘤防治工作的重点。[目的]探索上海市富碘食物摄入与乳头状甲状腺癌(PTC)之间的关系。[方法]采用以医院为基础的1∶1配对病例对照研究,按照性别、年龄(±3岁)配对,共纳入402对病例和对照,所有病例均为新发病例,采用统一设计的结构化调查表和经验证的食物频率调查表,以面对面的方式,分别获得人口学和膳食摄入等资料。采用多因素条件logistic回归模型分析紫菜、海带、虾皮等富碘食物与PTC的关系。[结果]本研究共调查了402对PTC病例及对照,平均年龄为(41.17±11.51)岁。相较于对照组,PTC患者以低学历、体力型职业为主(P<0.05);更多PTC患者超重或肥胖、患有甲状腺良性病史和家族甲状腺相关疾病史(P<0.05);此外,两组人群在过去10年内拍摄CT次数上差异具有统计学意义(P<0.05)。多因素条件logistic回归分析显示,与不吃相比,食用富碘食物与PTC风险降低有关(<1次·周^(−1),OR=0.20,95%CI:0.12~0.35;1~2次·周^(−1),OR=0.18,95%CI:0.10~0.33;≥3次·周^(−1):OR=0.13,95%CI:0.04~0.44)(P<0.05)。其中,摄入紫菜(<1次·周^(−1),OR=0.18,95%CI:0.11~0.30;1~2次·周^(−1),OR=0.11,95%CI:0.05~0.23;≥3次·周^(−1),OR=0.15,95%CI:0.03~0.75),食用海带(<1次·周^(−1),OR=0.28,95%CI:0.18~0.43;1~2次·周^(−1),OR=0.24,95%CI:0.11~0.50)、食用虾皮(<1次·周^(−1),OR=0.44,95%CI:0.29~0.69;1~2次·周^(−1),OR=0.34,95%CI:0.18~0.65)与PTC风险降低有关(P<0.05)。去除甲状腺良性疾病史者后,结果显示食用富碘食物、紫菜、虾皮和海带仍与PTC风险降低有关(P<0.05)。[结论]PTC患者食用富碘食物的比例低于非PTC患者人群。
[Background]Thyroid carcinoma is a serious threat to human health in Shanghai and a focus of cancer prevention and treatment.[Objective]This study aims to assess the relationship between foods rich in iodine and papillary thyroid carcinoma(PTC).[Methods]In a hospital-based case-control study matched by gender and age(±3 years old),402 pairs of cases(new incidences)and controls were included and studied.A validated questionnaire and food frequency questionnaire survey was conducted face to face to obtain demographic characteristics and dietary intake.A multiple conditional logistic regression model was applied to explore the relationship between foods rich in iodine(including seaweeds,kelp,and dried shrimps)and PTC.[Results]The mean age of the participants was(41.17±11.51)years in this study.Compared with the controls,more cases had a lower education and a manual occupation(P<0.05);more cases were overweight or obese,had a history of benign thyroid conditions,and had a family history of thyroid diseases(P<0.05);the two groups were different in the frequency of CT examination in the past ten years(P<0.05).The results of multiple conditional logistic regression analysis showed that consumption of iodine-rich foods was associated with a lower risk of PTC(for<1 time per week,OR=0.20,95%CI:0.12−0.35;for 1−2 times per week,OR=0.18,95%CI:0.10−0.33;for≥3 times per week,OR=0.13,95%CI:0.04−0.44)(P<0.05).Specifically,those who consumed seaweeds(for<1 time per week,OR=0.18,95%CI:0.11−0.30;for 1−2 times per week,OR=0.11,95%CI:0.05−0.23;for≥3 times per week,OR=0.15,95%CI:0.03−0.75),kelp(for<1 time per week,OR=0.28,95%CI:0.18−0.43;for≤2 times per week,OR=0.24,95%CI:0.11−0.50),and dried shrimps(for<1 time per week,OR=0.44,95%CI:0.29−0.69;for≤2 times per week:OR=0.34,95%CI:0.18−0.65)had a lower risk of PTC(P<0.05).After excluding patients who had a history of benign thyroid conditions,the favorable association remained significant among patients who had consumption of iodine-rich foods,seaweeds,shrimps,and kelp(P<0.05).[Conclusion]Less PTC patients consume iodine-rich foods than the controls.
作者
夏曼曼
臧嘉捷
程浩然
宋峻
汪正园
朱虹
丁文彬
刘茶珍
盛峰松
吴凡
XIA Manman;ZANG Jiajie;CHENG Haoran;SONG Jun;WANG Zhengyuan;ZHU Hong;DING Wenbin;LIU Chazhen;SHENG Fengsong;WU Fan(Shanghai Songjiang District Center for Disease and Prevention,Shanghai 201620,China;Shanghai Municipal Center for Disease Control and Prevention,Shanghai 200336,China;Central Hospital of Songjiang District,Shanghai 201620,China;Shanghai Medical College of Fudan University,Shanghai 200032,China)
出处
《环境与职业医学》
CAS
CSCD
北大核心
2021年第11期1185-1191,共7页
Journal of Environmental and Occupational Medicine
基金
上海市公共卫生体系建设三年行动计划学科带头人项目(GWV-10.2-XD18)
上海市第五轮公共卫生体系建设三年行动计划重点学科项目(GWV-10.1-XK11)
上海市公共卫生体系建设三年行动计划优青计划(GWV-10.2-YQ22)
上海市青年拔尖人才项目(无)
上海市卫生健康委员会科研课题(20194Y0443)
达能营养中心膳食营养研究与宣教基金(DIC2019-03)。
关键词
乳头状甲状腺癌
富碘食物
病例对照研究
papillary thyroid carcinoma
iodine-rich food
case-control study
