摘要
目的探讨亮丙瑞林在子宫内膜异位症患者腹腔镜手术后的应用效果。方法抽取2019年10月至2020年10月安阳市妇幼保健院收治的子宫内膜异位症患者82例,依据治疗方法分为观察组(41例)与对照组(41例)。对照组采用腹腔镜手术治疗,观察组在采用腹腔镜手术治疗后给予亮丙瑞林微球治疗。比较两组疗效,治疗前后子宫动脉血流参数,血清血管内皮生长因子(VEGF)、糖类抗原125(CA125)水平,性激素变化及子宫内膜厚度变化。结果观察组总有效率为95.12%,高于对照组的78.05%,P<0.05。两组治疗后子宫动脉搏动指数(PI)和阻力指数(RI)低于治疗前(P<0.05);观察组治疗后PI和RI低于对照组(P<0.05)。两组治疗后血清VEGF和CA125水平低于治疗前(P<0.05);观察组治疗后血清VEGF和CA125水平低于对照组(P<0.05)。两组治疗后血清雌二醇(E2)、卵泡雌激素(FSH)和黄体生成素(LH)水平低于治疗前(P<0.05);观察组治疗后血清E2、FSH和LH水平低于对照组(P<0.05)。两组治疗后子宫内膜厚度大于治疗前(P<0.05);观察组治疗后子宫内膜厚度大于对照组(P<0.05)。结论亮丙瑞林对子宫内膜异位症腹腔镜手术患者疗效良好,可改善患者子宫动脉血流变化,降低血清VEGF和CA125表达,改善性激素水平。
Objective To investigate the effect of leuprolide on patients after laparoscopic surgery for endometriosis.Methods A total of 82 patients with endometriosis in Anyang Maternal and Child Health Hospital from October 2019 to October 2020 were selected,and divided into observation group(41 cases)and control group(41 cases)according to the treatmentl method.Patients in the control group were treated with laparoscopic surgery,and patients in the observation group were treated with leuprolide microspheres on the basis of the control group.The therapeutic effects of the two groups were compared;the uterine artery blood flow parameters,serum vascular endothelial growth factor(VEGF),carbohydrate antigen 125(CA125)levels,sex hormones changes and endometrial thickness changes were compared before and after treatment.Results The total effective rate of patients with endometriosis in the observation group was 95.12%,which was higher than 78.05%in the control group(P<0.05).After treatment,uterine artery pulsation index(PI)and resistance index(RI)of the two groups were lower than those before treatment(P<0.05);PI and RI of the observation group were lower than those of the control group(P<0.05).After treatment,the serum VEGF and CA125 levels of the two groups were lower than those before treatment(P<0.05);the serum VEGF and CA125 levels of the observation group were lower than those of the control group(P<0.05).After treatment,the serum estradiol(E2),follicular estrogen(FSH)and luteinizing hormone(LH)levels of the two groups were lower than those before treatment(P<0.05);the serum E2,FSH and LH levels of the observation group lower than those of the control group(P<0.05).After treatment,the endometrial thickness of the two groups were higher than that before treatment(P<0.05);the endometrial thickness of the observation was group the observation group higher than that of the control group after treatment(P<0.05).Conclusions Leuprolide has a good curative effect on patients undergoing laparoscopic endometriosis.It can improve the blood flow of the uterine artery,reduce the expression of serum VEGF and CA125,and improve the level of sex hormones.
作者
卢淑丽
崔麦玲
王雯
李娜
Lu Shuli;Cui Mailing;Wang Wen;Li Na(Department of Obstetrics and Gynecology,Anyang Maternal and child Health Hospital,Anyang 455000,China)
出处
《中国实用医刊》
2021年第22期110-113,共4页
Chinese Journal of Practical Medicine
