摘要
目的:了解疏肝清热方联合左甲状腺素钠片在桥本甲状腺炎患者中的应用价值。方法:选取2019年11月-2020年11月安陆市普爱医院诊治的80例桥本甲状腺炎患者。根据随机数字表法将其分成对照组和观察组,每组40例。对照组单用左甲状腺素钠片治疗,观察组以疏肝清热方联合左甲状腺素钠片进行治疗。对比两组临床疗效,治疗前后甲状腺功能指标[血清游离甲状腺素(FT_(4))、游离三碘甲腺原氨酸(FT_(3))、促甲状腺激素(TSH)],甲状腺自身抗体[甲状腺球蛋白抗体(TGAb)、抗甲状腺过氧化物酶自身抗体(TPOAb)]水平,甲状腺体积与峡部厚度。结果:观察组总有效率高于对照组(97.5%vs 77.5%)(P<0.05)。两组治疗前FT_(3)、FT_(4)、TSH、TPOAb、TGAb水平及甲状腺体积、峡部厚度比较差异均无统计学意义(P>0.05);治疗后观察组FT_(3)、FT_(4)水平分别为(7.52±1.23)、(18.16±3.11)pmol/L,均高于对照组的(6.33±1.21)、(16.47±3.02)pmol/L(P<0.05);治疗后观察组TSH水平为(2.04±0.21)mIU/L,低于对照组的(3.44±0.61)mIU/L(P<0.05);治疗后观察组TPOAb、TGAb水平分别为(281.42±55.21)、(233.21±47.25)IU/ml,均低于对照组的(396.24±80.16)、(377.24±78.82)IU/ml(P<0.05);治疗后两组甲状腺体积、峡部厚度均有所减小,且观察组甲状腺体积、峡部厚度均小于对照组(P<0.05)。结论:对桥本甲状腺炎患者采取疏肝清热方联合左甲状腺素钠片治疗的方案,对患者甲状腺功能、甲状腺自身抗体水平改善有显著作用,效果显著。
Objective:To understand the application value of Shugan Qingre Fang combined with Levothyroxine Sodium Tablets in patients with Hashimoto thyroiditis.Method:A total of 80 patients with Hashimoto thyroiditis who were diagnosed and treated in Pu’ai Hospital of Anlu City from November 2019 to November 2020 we re selected.They were divided into the control group and observation group by random number table method,40 patients in each group.The control group was treated with Levothyroxine Sodium Tablets alone,and the observation group was treated with Shugan Qingre Fang combined with Levothyroxine Sodium Tablets.The clinical efficacy,thyroid function indexes[serum free thyroxine(FT_(4)),free triiodothyronine(FT_(3)),thyroid stimulating hormone(TSH)],thyroid autoantibody[thyroglobulin antibody(TGAb),anti-thyroid peroxidase autoantibody(TPOAb)]level,thyroid volume and isthmus thickness before and after treatment were compared between the two groups.Result:The total effective rate of observation group was higher than that of control group(97.5%vs 77.5%)(P<0.05).There were no significant differences in FT_(3),FT_(4),TSH,TPOAb and TGAb levels,thyroid volume and isthmus thickness between the two groups before treatment(P>0.05).After treatment,the levels of FT_(3) and FT_(4) in the observation group were(7.52±1.23),(18.16±3.11)pmol/L respectively,which were higher than(6.33±1.21),(16.47±3.02)pmol/L in the control group(P<0.05);after treatment,the TSH level of the observation group was(2.04±0.21)mIU/L,which was lower than(3.44±0.61)mIU/L of the control group(P<0.05);after treatment,the levels of TPOAb and TGAb of the observation group were(281.42±55.21),(233.21±47.25)IU/ml respectively,which were lower than (396.24±80.16), (377.24±78.82) IU/ml of the control group (P<0.05);after treatment, thyroid volume and isthmus thickness decreased in both groups, the thyroid volume and isthmus thickness of the observation group were smaller than those of the control group (P<0.05). Conclusion: For patients with hashimoto thyroiditis, the treatment plan of Shugan Qingre Fang combined with Levothyroxine Sodium Tablets has a significant effect on the improvement of thyroid function and thyroid autoantibody level. Its curative effect is remarkable.
作者
程晓莉
江涛
胡爱军
CHENG Xiaoli;JIANG Tao;HU Aijun(Pu’ai Hospital of Anlu City,Anlu 432600,China)
出处
《中外医学研究》
2022年第2期5-8,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
