摘要
目的:观察高血压合并冠心病患者采用阿司匹林合并阿托伐他汀钙片治疗6个月后患者血压、血脂等指标水平。方法:收集80例高血压合并冠心病患者,按照盲选法40例一组分为SP组和联合组,前者在基础干预上口服阿托伐他汀钙片,后者在上组干预方法上口服阿司匹林片,治疗时间6个月为1个疗程。观察血压、血脂代谢、内皮素(ET)和一氧化氮(NO)水平及心功能的影响。结果:用药前,SP组和联合组患者舒张压(DBP)、收缩压(SBP)、总胆固醇(TC)、三酰甘油(TG)和高密度脂蛋白胆固醇(HDL-C)比较差异无统计学意义(P>0.05),用药6个月后,上述指标均改善,HDL-C含量升高其余指标下降,联合组与SP组差异有统计学意义(P<0.05);SP组和联合组给药前血清ET与NO水平比较,差异无统计学意义(P>0.05),经过6个月治疗后,ET均降低,联合组与SP组比较,差异有统计学意义(P<0.05),NO水平与ET水平表达相反,差异有统计学意义(P<0.05);SP组和联合组给药前心功能比较,差异无统计学意义(P>0.05),经过6个月治疗后,左室射血分数(LVEF)升高,联合组与SP组比较存在不同,差异有统计学意义(P<0.05),左室舒张末内径(LVDD)水平与之相反,差异有统计学意义(P<0.05)。结论:阿司匹林合并阿托伐他汀钙片改善高血压合并冠心病血压、血脂水平,降低ET水平,增加心脏射血功能。
Objective To observe the blood pressure and blood lipids of patients with hypertension and coronary heart disease after 6 months of treatment with aspirin and atorvastatin calcium tablets.Method 80 patients with hypertension and coronary heart disease were collected.According to the blind selection method,they were divided into SP group and combined group,a group of 40 cases.The former was taken orally with atovar based on basic intervention Statin calcium tablets,the latter took aspirin tablets orally in the intervention method of the previous group,and the treatment time was 6 months as a course of treatment.The effects of blood pressure,blood lipid metabolism,ET and NO levels and heart function was observed.Results Before the medication,there was no difference in DBP,SBP,TC,TG and HDL-C between the SP group and the combination group(P>0.05).After 6 months of medication,the above indicators were improved,and the HDL-C content increased and the remaining indicators decreased.There was a gap between the combination group and the SP group(P<0.05);the SP group and the combination group had similar levels of serum ET and NO before administration(P>0.05).After 6 months of treatment,ET decreased,and the combination group was compared with SP group.There were differences in comparison(P<0.05),the expression of NO level was opposite to ET level(P<0.05);the heart function before administration of SP group and combination group was similar(P>0.05),after 6 months of treatment,LVEF%increased highly,the combination group was different from SP group(P<0.05),and the LVDD level was opposite to it(P<0.05).Conclusion Aspirin combined with atorvastatin calcium tablets can improve blood pressure and blood lipid levels in hypertension complicated with coronary heart disease,reduce ET levels,and increase cardiac ejection function.
作者
李境珠
张敬钊
LI Jing-zhu;ZHANG Jing-zhao(Department of pharmacy,Maoming Hospital of traditional Chinese Medicine,Maoming 525000,China)
出处
《吉林医学》
CAS
2022年第1期159-162,共4页
Jilin Medical Journal
关键词
高血压合并冠心病
阿司匹林
阿托伐他汀钙
血脂
血压
心功能
Hypertension with coronary heart disease
Aspirin
Atorvastatin calcium
Blood lipids
Blood pressure
Cardiac function
