摘要
目的建立适合中国儿童的SCORTEN评分模型。方法回顾性分析医院2010年1月至2021年1月收治的55例中毒性表皮坏死松解症(TEN)患儿的一般资料、病因、治疗、并发症等,评估TEN(包括与Stevens-Johnson综合征重叠)患儿的预后及影响死亡的风险因素。结果TEN的病死率为14.5%;接受类固醇注射联合免疫球蛋白治疗的患儿组标准化死亡率最低;Logistic回归分析显示,心率超标>20%、恶性肿瘤、表皮脱落率>30%、血尿素氮>25 mg/dL、血清碳酸氢盐<21.6 mEq/L、血糖>210 mg/dL、病程>7.5 d和入院后合并急性肺损伤对TEN的预后有明显影响。结论根据前述8项指标建立改良严重度评分模型,可能有助于预测近期TEN患儿的预后。
Objective To establish a SCORTEN scoring model suitable for Chinese children.Methods The general data,etiology,treatment and complications of 55 children with toxic epidermal necrolysis(TEN)treated in the hospital from January 2010 to January 2021 were analyzed retrospectively.The prognosis and risk factors affecting death of children with TEN(including overlap with Stevens-Johnson syndrome)were evaluated.Results The mortality of TEN was 14.5%.The standardized mortality was the lowest in the group treated with steroid injection combined with immunoglobulin.Logistic regression analysis showed that excessive heart rate>20%,malignant tumor and epidermal exfoliation rate>30%,blood urea nitrogen>25 mg/dL,serum bicarbonate<21.6 mEq/L,blood glucose>210 mg/dL,course of disease>7.5 d and acute lung injury after admission had a significant impact on the prognosis of TEN.Conclusion The improved severity score model based on the above eight indexes may be helpful to predict the prognosis of children with TEN in the near future.
出处
《中国药业》
CAS
2021年第S01期66-67,共2页
China Pharmaceuticals
基金
河北省卫生和计划生育委员会科研基金项目[20200636]。
