摘要
高原低氧环境通过改变机体胃肠排空速率、器官血流量、药物血浆蛋白结合率、药物代谢酶和转运体表达等影响药物的药代谢动力学过程。癫痫是一种需长期用药的脑部疾病,而大多数抗癫痫药物的治疗指数低、有效血药浓度范围窄。临床上常用治疗药物监测(therapeutic drug monitoring,TDM)来寻找抗癫痫药物的最佳个体化用药方法。该文对临床上常用抗癫痫药及其治疗窗进行归纳总结,并分析高原低氧环境对抗癫痫药物药代动力学的影响,为高原抗癫痫药物临床用药提供参考。
The high altitude hypoxic environment affects the pharmacokinetic process of drugs by changing the body’s gastrointestinal emptying rate,organ blood flow,drug plasma protein binding rate,drug metabolizing enzymes and transporter expression.Epilepsy is a brain disease that requires long-term medication.Most anti-epileptic drugs have a low therapeutic index and a narrow range of effective blood drug concentrations.Therapeutic drug monitoring(TDM)is commonly used clinically to find the best individualized medication method for antiepileptic drugs.This article summarizes the commonly used anti-epileptic drugs and their treatment windows in clinical practice,and analyzes the influence of the pharmacokinetics of anti-epileptic drugs in the high altitude hypoxic environment,so as to provide reference for the clinical use of anti-epileptic drugs at high altitude.
作者
胡琳
黄隆基
秦宁宁
申亦可
赵安鹏
李文斌
王荣
HU Lin;HUANG Long-ji;QIN Ning-ning;SHEN Yi-ke;ZHAO An-peng;Li Wen-bing;WANG Rong(Dept of Pharmacy, the 940th Hospital of Joint Logistics Support force of Chinese People’s Liberation Army, Lanzhou 730050, China;College of Pharmacy, Lanzhou University, Lanzhou 730000, China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2022年第2期181-184,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 81673508)
中央高校基本科研业务费专项(No 3192020009)
甘肃省青年科技基金计划(No 20JR10RA014)
联勤保障部队第九四〇医院院内应急医学科研项目(No 20yjky017)。
关键词
抗癫痫药
治疗药物监测
药物浓度
高原低氧
合理用药
药物代谢
antiepileptic drugs
therapeutic drug monitoring
drug concentration
altitude hypoxia
rational use
drug metabolism
