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Highly responsive biosensors based on organic field-effect transistors under light irradiation

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摘要 High responsivity and sensitivity play essential roles in the development of organic field-effect transistors(OFETs)-based biosensors with regard to biological detections,particularly for disease diagnosis.Nonetheless,how to design a biosensor which improves these two outstanding properties while achieving low cost,easy processing,and time saving is a daunting challenge.Herein,a novel biosensor based on OFET with copolymer thin film,whose surface is illuminated with a suitable light beam is reported.This film can be used as both an organic semiconductor material and as a photoelectric active material.Due to amplification of signals as a result of the film’s strong response to light,the biosensor possesses higher responsivity and sensitivity compared to dark condition and even realizes a maximum responsivity of up to 10^(3)for alpha-fetoprotein(AFP)detection.The simple combination of light and transistor builds a bridge between photoelectric effect and biological system.In addition,the emergence of more excellent photoelectric active materials is expected to pave a way for ultrasensitive bio-chemical diagnostic tools.
出处 《Chinese Chemical Letters》 SCIE CAS CSCD 2021年第11期3364-3367,共4页 中国化学快报(英文版)
基金 financially supported by the Ministry of Science and Technology of China(Nos.2015CB856502,2016YFB0401100 and 2017YFA0204503) National Natural Science Foundation of China(Nos.21705116,51733004,91433115,51633006,51703160,21661132006,21473222 and 51902131).
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