摘要
目的观察止颤汤治疗帕金森病运动并发症的临床疗效。方法采用双盲、安慰剂平行对照临床试验设计,将100例帕金森病运动并发症患者,随机分为治疗组(50例)与对照组(50例),两组在原有治疗方案上,治疗组加服止颤汤颗粒剂,对照组加服止颤汤颗粒安慰剂,疗程12周,每4周随访1次,比较两组帕金森病综合评分量表IV(UPDRS IV)、不自主运动评定量表(AIMS)、中医证候量表评分,评价患者帕金森病运动并发症改善情况。结果治疗后治疗组各项评分随时间改善,UPDRSIV、UPDRSIV-A、中医证候评分从第8周起与对照组比较,差异有统计学意义(P<0.05或P<0.01),AIMS肢体部分评分在12周时与对照组比较,差异有显著统计学意义(P<0.01);与对照组相比,治疗组中医证候疗效有明显改善(P<0.01)。结论止颤汤治疗帕金森病运动并发症有效。
Objective To observe the clinical effect of Zhichan Decoction in the treatment of motor complication of Parkinson′s disease(PD).Methods Totally 100 patients with motor complications of PD were enrolled in a doubleblind,placebo-controlled parallel group clinical trial design,and were divided into a treatment group(50 cases)and control group(50 cases).On the basis of the original treatment plan,the treatment group received Zhichan Decoction granule,and the control group received Zhichan Decoction granule placebo.During the 12-week treatment course,each patient received a follow-up visit every 4 weeks.The unified PD rating scale IV(UPDRS IV),Abnormal Involuntary Movement Scale(AIMS),Traditional Chinese Medicine Syndrome Score Scale(TCMSSS)were compared.The improvement of patients with Parkinson′s disease movement complications were compared.Results After treatment,the scores of the treatment group improved over time.The scores of UPDRSIV,UPDRSIV-A,and TCM syndromes were compared with those of the control group from the 8 thweek,and the differences were statistically significant(P<0.05 or P<0.01).The AIMS limb scores were compared with the control group at 12 weeks,and the difference was statistically significant(P<0.01).Compared with the control group,the treatment group showed significant improvement in the efficacy of TCM syndromes(P<0.01).Conclusion The effect of Zhichan decoction in the treatment of motor complications of PD is ideal.
作者
黄宁静
徐子入
毛明宇
朱金诺
刘毅
李文涛
Ningjing Hunag;Xu Ziru;Mao Mingyu;Zhu Jinnuo;Liu Yi;Li Wentao(Shanghai University of Traditional Chinese Medicine Affiliated Chinese Medicine Hospital,Shanghai 200071,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2021年第10期3801-3807,共7页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
上海市卫生健康委员会面上项目(202140117):止颤颗粒对帕金森病(肝肾不足、气血两虚型)患者肠道菌群影响的随机双盲安慰剂对照临床研究
负责人:黄宁静
上海中医药大学预算内项目(2021LK068):基于p62/mTOR信号通路探讨止颤汤调节自噬治疗异动症的机制研究,负责人:黄宁静
国家自然科学基金委员会青年项目(81703999):止颤汤对帕金森病大鼠P62-LC3信号通路调节促进a-syn代谢的研究,负责人:黄宁静。
关键词
止颤汤
帕金森病
运动并发症
Zhichan Decoction
Parkinson′s disease
Motor complications
