摘要
神经退行性疾病包括阿尔茨海默病、帕金森病等,严重影响患者的生存质量。肠道菌群参与神经退行性疾病的发生发展。其中,菌-肠-脑轴是肠道菌群影响神经退行性疾病的重要途径。而肠道菌群也是神经免疫系统发育和发挥作用的关键因素。作为一条双向通道,菌-肠-脑轴主要通过神经免疫系统等方式连接肠道菌群与大脑,且神经退行性疾病可能起源于肠道神经免疫系统。深入研究肠道菌群与神经免疫系统及复杂神经退行性疾病的相互作用机制,可为神经退行性疾病的预防和治疗提供新思路。
Neurodegenerative diseases(including Alzheimer′s disease and Parkinson′s disease,etc.)seriously affect the life quality of the patients.The gut microbiota plays a role in the occurrence and development of neurodegenerative diseases,in which the microbiota-gut-brain axis is an important pathway.The gut microbiota is also a key factor in the development and function of neuroimmune system.As a two-way channel,the microbiota-gut-brain axis mainly connects the gut microbiota and the brain through the neuroimmune system,and neurodegenerative diseases may originate from the enteric neuroimmune system.Revealing the interaction mechanism of the gut microbiota,the neuroimmune system and complex neurodegenerative diseases can provide new ideas for the prevention and treatment of neurodegenerative diseases.
作者
曹原
曹展
高耀辉
蔚青
秦环龙
CAO Yuan;CAO Zhan;GAO Yaohui;WEI Qing;QIN Huanlong(Department of Pathology,the Tenth People′s Hospital of Tongji University,Shanghai 200072,China;Shanghai Institution of Gut Microbiota Research and Engineering Development,the Tenth People′s Hospital of Tongji University,Shanghai 200072,China;Department of Gastrointestinal Surgery,the Tenth People′s Hospital of Tongji University,Shanghai 200072,China)
出处
《医学综述》
CAS
2022年第2期209-215,共7页
Medical Recapitulate
基金
国家自然科学基金(81802886)。
关键词
阿尔茨海默病
帕金森病
菌-肠-脑轴
肠道菌群
神经免疫
Alzheimer′s disease
Parkinson′s disease
Microbiota-gut-brain axis
Gut microbiota
Neuroimmunity
