摘要
目的分析肿瘤患者经外周静脉穿刺的中心静脉导管(PICC)置管前后的血液相关指标变化。方法收集284例明确诊断为恶性肿瘤并留置PICC的患者资料,比较其置管前3 d与置管后3 d的红细胞相关参数、凝血功能指标、血小板相关参数等。结果患者置管后3 d的红细胞计数、血红蛋白、血细胞比容、血小板计数、血小板压积均低于置管前3 d(均P<0.05),红细胞分布宽度、平均血小板体积均高于置管前3 d(均P<0.05)。患者置管后3 d的血小板分布宽度及凝血功能指标(包括凝血酶原时间、活化部分凝血活酶时间、凝血酶时间、纤维蛋白原)与置管前3 d比较,差异均无统计学意义(均P>0.05)。结论PICC置管对肿瘤患者血液系统的主要影响是红细胞和血小板相关参数的变化,此外,置管后3 d可能是凝血系统激活的关键时期,必要时应进行血栓监测和预防。
Objective To analyze the changes in blood-related indicators in tumor patients before and after peripherally inserted central venous catheter(PICC)catheterization.Methods The data of 284 patients definitely diagnosed as malignant tumor and with indwelled PICC were collected.The erythrocyte-related parameters,coagulation function indicators,and platelet-related parameters three days before the catheterization were compared with those three days after the catheterization.Results Erythrocyte count,hemoglobin,hematocrit,platelet count,and plateletcrit were lower(all P<0.05),and RBC distribution width and mean platelet volume were higher three days after the catheterization than three days before the catheterization(all P<0.05).Patients′platelet distribution width and coagulation function indicators(including prothrombin time,activated partial thromboplastin time,thrombin time,fibrinogen)three days after the catheterization did not statistically differ from those three days before the catheterization(all P>0.05).Conclusion The primary effects of PICC catheterization on the blood system of tumor patients are the changes in erythrocyte-and platelet-related parameters.In addition,three days after the catheterization may be a critical period for the activation of the coagulation system,and thrombus monitoring and prevention should be carried out if necessary.
作者
韦佳妮
应燕萍
赵慧函
卢婷
文萃
WEI Jia-ni;YING Yan-ping;ZHAO Hui-han;LU Ting;WEN Cui(Department of Nursing,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)
出处
《广西医学》
CAS
2021年第24期2897-2900,3005,共5页
Guangxi Medical Journal
基金
国家自然科学基金(81860032)
广西自然科学基金(2018GXNSFAA050081)
广西医科大学第一附属医院护理临床研究攀登计划高峰项目(YYZS2020025)。