摘要
目的:探讨大剂量肺表面活性物质(PS)联合持续气道正压通气(CAPA)治疗新生儿呼吸窘迫综合征(NRDS)的效果。方法:NRDS患儿96例,随机分成两组,每组48例。小剂量组采用小剂量PS+CAPA治疗,大剂量组采用大剂量PS+CAPA治疗。比较两组疗效、一般观察指标、动脉血气指标、血清骨形态发生蛋白-7(BMP-7)、转化生长因子β1(TGF-β1)及并发症。结果:大剂量组治疗的总有效率95.83%高于小剂量组81.25%(P<0.05);治疗后,大剂量组呼吸困难改善时间、无创通气时间、吸氧时间、住院时间短于小剂量组(P<0.05);治疗后,大剂量组血氧分压(PaO_(2))高于小剂量组,二氧化碳分压(PaCO_(2))、吸氧浓度(FiO_(2))低于小剂量组,血清BMP-7、TGF-β1水平低于小剂量组(P<0.05);大剂量组并发症发生率6.25%低于小剂量组20.83%(P<0.05)。结论:大剂量PS联合CAPA治疗NRDS患儿能改善临床症状和血气指标,疗效更好。
Objective: To investigate the effects of the first large dose of pulmonary surfactant(PS)combined with continuous positive airway pressure(CPAP)in the treatment of neonatal respiratory distress syndrome(NRDS). Methods: A total of 96 NRDS children were randomized into two groups, each with 48 cases. The low-dose group was treated with the low-dose PS combined with CPAP, while the high-dose group received the treatment with the high-dose PS combined with CAPA. Then, the curative effect, clinical indicators, arterial blood gas index, serum bone morphogenetic protein-7(BMP-7), transforming growth factor beta 1(TGF-β1)levels and the incidence of complications were compared between the two groups. Results: The total effective rate of the high-dose group was 95.83%, higher than 81.25% of the low-dose group(P<0.05);the improvement time of dyspnea, noninvasive ventilation, oxygen inhalation and hospitalization in the high-dose group was shorter than that in low-dose group(P< 0.05) after treatment;PaO_(2)in the high-dose group were higher than that in low-dose group, PaCO_(2)and FiO_(2)were lower than those in low-dose group(P<0.05);serum BMP-7 and TGF-β1 levels in the high-dose group were lower than those in the low-dose group after treatment;the incidence of complications in the high-dose group was 6.25%, lower than 20.83% in the low-dose group(P<0.05). Conclusion: The high-dose PS combined with CPAP is effective in the treatment of children with NRDS, which can improve the clinical symptoms and blood gas indicators of patients.
作者
靳若欣
JIN Ruoxin(The 3rd People's Hospital of Luohe,Luohe 462300,China)
出处
《华夏医学》
CAS
2021年第6期44-48,共5页
Acta Medicinae Sinica
关键词
肺表面活性物质
持续气道正压通气
新生儿
呼吸窘迫综合征
pulmonary surfactant
continuous positive airway pressure(CPAP)
neonate
respiratory distress syndrome
