摘要
目的:探讨头孢哌酮舒巴坦联合奥硝唑治疗儿童急性化脓性阑尾炎的临床疗效并进行经济学评价。方法:采用等距抽样法,选取2020年1~12月郑州大学附属儿童医院普外科急性化脓性阑尾炎患儿200例,进行回顾性分析,分为对照组和观察组各100例,对照组采用头孢哌酮舒巴坦静脉滴注治疗,观察组在对照组治疗方案的基础上加用奥硝唑静脉滴注治疗。对比2组患儿在临床疗效、药品不良反应发生率以及经济学评价方面的差异。结果:观察组总体有效率为100%,对照组总体有效率为99.0%,2组总体有效率相比,差异无统计学意义(P>0.05);观察组药品不良反应总体发生率为4.0%;对照组药品不良反应总体发生率为2.0%,2组药品不良反应总体发生率相比,差异无统计学意义(P>0.05);药物经济学评价采用最小成本法,观察组平均总成本为21289.50元,对照组平均总成本为19578.57元,敏感性分析结果与基本分析结果一致,提示药物经济学分析结果可靠。结论:头孢哌酮舒巴坦联合奥硝唑治疗儿童急性化脓性阑尾炎与单用头孢哌酮舒巴坦相比,临床疗效相当,但治疗费用更高,单用头孢哌酮舒巴坦治疗方案更值得临床应用。
OBJECTIVE To investigate the clinical efficacy and economic evaluation of cefoperazone-sulbactam combined with ornidazole in the treatment of acute suppurative appendicitis in children.METHODS Totally 200 children with acute suppurative appendicitis in Department of General Surgery,Children’s Hospital Affiliated to Zhengzhou University from January to December 2020 were randomly selected for the retrospective analysis by isometry.They were divided into control group(n=100)and observation group(n=100).The control group was treated with intravenous infusion of cefoperazone and sulbactam.The observation group was treated with ornidazole intravenous drip on the basis of the treatment regimen of the control group.The differences in clinical efficacy,incidence of adverse drug reactions and economic evaluation between the two groups were compared.RESULTS The total effective rate of the observation group was 100%,and the total effective rate of the control group was 99.0%,and there was no statistical significance between the two groups(P>0.05).The overall incidence of adverse drug reactions in the observation group was 4.0%,the overall incidence of adverse drug reactions in the control group was 2.0%,and there was no statistically significant difference between the two groups(P>0.05).The cost minimization method was used for pharmacoeconomic evaluation.The average total cost of the observation group was 21289.50 yuan,and that of the control group was 19578.57 yuan.The sensitivity analysis results were consistent with the basic analysis results,suggesting that the pharmacoeconomic analysis results were reliable.CONCLUSION In the treatment of children with acute suppurative appendicitis,cefoperazone-sulbactam combined with ornidazole has similar clinical efficacy compared with cefoperazone-sulbactam alone,but the treatment cost is higher,suggesting cefoperazone-sulbactam alone is more worthy of clinical application.
作者
裴保方
曹松山
张飞
陶兴茹
PEI Bao-fang;CAO Song-shan;ZHANG Fei;TAO Xing-ru(Department of Pharmacy,Children's Hospital Affiliatedto Zhengzhou University/Henan Children's Hospital,Henan Zhengzhou 450018,China;Department of General Surgery,Children's Hospital Affiliated to Zhengzhou University/Henan Children's Hospital,Henan Zhengzhou 450018,China)
出处
《中国医院药学杂志》
CAS
北大核心
2022年第1期45-48,共4页
Chinese Journal of Hospital Pharmacy
基金
河南省医学科技攻关计划联合共建项目(编号:LHGJ20200629)。
关键词
头孢哌酮舒巴坦
奥硝唑
儿童
急性化脓性阑尾炎
疗效观察
经济学评价
cefoperazone-sulbactam
ornidazole
children
acute suppurative appendicitis
clinical observation
economic evaluation
