摘要
目的:探讨子痫前期患者血清脑钠肽(BNP)、Ⅲ型前胶原氨基端肽(PⅢNP)表达水平与心功能相关性。方法:选取2018年12月-2020年10月本院治疗的62例子痫前期患者为子痫前期组,78例妊娠期高血压患者为妊娠期高血压组,80例产前检查健康孕妇为正常妊娠组。收集各组一般资料,采用彩色多普勒超声诊断仪对孕妇进行心脏超声检测,获取左室射血分数(LVEF)、心脏指数(CI)、心输出量(CO)、舒张早期峰值速度(E)、舒张晚期峰值速度(A)、E/A;采用酶联免疫吸附法检测血清BNP、PⅢNP水平;采用Pearson法分析子痫前期患者血清BNP、PⅢNP水平与心功能指标相关性。结果:正常妊娠组、妊娠期高血压组、子痫前期组BNP、PⅢNP、A、CO、TG水平依次升高,E、E/A、LVEF、CI水平依次降低(均P<0.05)。子痫前期患者血清BNP与PⅢNP水平呈正相关,BNP和PⅢNP与A、CO均呈正相关,与E、E/A、LVEF、CI均呈负相关(均P<0.05)。结论:子痫前期患者血清BNP、PⅢNP水平与超声心动图指标相关,临床可采用BNP、PⅢNP水平检测结合超声心动图检查对子痫前期患者病情发展给予及时判断。
Objective: To investigate the correlation between the expressions levels of serum brain natriuretic peptide(BNP) and procollagen type Ⅲ N-terminal peptide(PⅢNP) of the pregnant women with preeclampsia and their cardiac function. Methods: A total of 62 pregnant women with preeclampsia were selected in group A, 78 pregnant women with pregnancy induced hypertension were selected in group B, and 80 healthy pregnant women were selected in group C from December 2018 to October 2020. The general data of the women in the three groups were collected. The cardiac uhrasonography indexes, such as left ventricular ejection fraction(LVEF), cardiac index(CI), cardiac output(CO), early diastolic peak velocity(E), late diastolic peak velocity(A), and E/A of the women in the three groups were measured by color Doppler ultrasound. The levels of serum BNP and PⅢNP were detected by enzyme-linked immunosorbent assay(ELISA). The correlation between serum BNP and PⅢNP levels of the women with preeclampsia and their cardiac function was analyzed by Pearson method. Results: The levels of BNP and PⅢNP, and the values of A, CO, and TG of the women in group C, group B, and group A had increased in turn, while the values of E, E/A, LVEF and CI of the women in group C, group B, and group A had decreased in turn(all P<0.05). There was positive correlation between the serum BNP level of the women with preeclampsia and their serum PⅢNP level. The levels of serum BNP and PⅢNP of the women with preeclampsia were positively correlated with their values of A and CO, but which were negatively correlated with their values of E, E/A, LVEF, and CI(all P<0.05). Conclusion: The serum BNP and PⅢNP levels of the women with preeclampsia were significantly correlated with their echocardiographic parameters. The serum BNP and PⅢNP levels combined with echocardiography examination can judge the development of preeclampsia timely in clinic.
作者
张温
刘宏健
宋欣
李宝
韩素坤
高媛媛
ZHANG Wen;LIU Hongjian;SONG Xin;LI Bao;HAN Sukun;GAO Yuanyuan(Cangzhou People's Hospital, Hebei Province, 061000)
出处
《中国计划生育学杂志》
2021年第10期2177-2180,共4页
Chinese Journal of Family Planning
基金
沧州市科技支撑计划项目(151302058)。
关键词
子痫前期
脑钠肽
Ⅲ型前胶原氨基端肽
心功能
相关性
Preeclampsia
Brain natriuretic peptide
Type Ⅲ procollagen N-terminal peptide
Cardiac function
Correlation
