摘要
目的观察苏黄止咳胶囊辅助治疗老年肺癌相关咳嗽的临床疗效。方法将78例65岁以上的肺癌咳嗽患者采用抽签分组法分为2组,2组均采用常规化疗治疗。对照组39例予磷酸可待因片治疗,治疗组39例予苏黄止咳胶囊治疗,2组疗程均为14 d。比较2组治疗前后症状体征评分、咳嗽评分、第1 s用力呼气容积(FEV 1)、用力肺活量(FVC)及辅助性T淋巴细胞(Th细胞)、抑制性T淋巴细胞(Ts细胞)水平和Th/Ts比值。结论治疗后2组各症状体征评分及日间、夜间咳嗽评分均较本组治疗前降低,且治疗组均低于对照组,比较差异均有统计学意义(P<0.05)。治疗后2组肺功能指标FEV 1、FVC均较本组治疗前升高,且治疗组均高于对照组,比较差异均有统计学意义(P<0.05)。治疗后,治疗组Th细胞水平、Th/Ts比值均较本组治疗前升高,Ts细胞水平均较本组治疗前降低,且治疗组Th细胞水平及Th/Ts比值高于对照组,Ts细胞水平低于对照组,比较差异均有统计学意义(P<0.05)。结论苏黄止咳胶囊辅助治疗老年肺癌相关咳嗽可改善机体免疫,减轻咳嗽,进而改善肺功能。
Objective To observe the clinical effect of Su Huang cough capsule in adjuvant therapy of elderly lung cancer-related cough.Methods Totally 78 elderly patients(>65 years)with lung cancer-related cough were divided into equal group by drawing lots,in addition to routine chemotherapy,control group received codeine phosphate tablets,and treatment group received Su Huang cough capsule.The treatment period was 14 days,aiming to compare symptoms and signs score,cough scores,forced expiratory volume in one second(FEV 1),forced vital capacity(FVC),absolute value of T helper lymphocytes(Th)and suppressor t lymphocytes(Ts),Th/Ts ratio.Results After treatment,symptoms and signs score,daytime and nighttime cough scores in groups were decreased,which were lower in treatment group than in control group,and with statistically significant difference(P<0.05);pulmonary function indexes(FEV 1,FVC)in groups were increased,which in treatment group were increased as comparison to control group,the difference of two groups being significant(P<0.05);absolute value of Th,Th/Ts ratio in groups were increased,which increased in treatment group compared with cortrol group,absolute value of Ts in groups was decreased,which was lower in treatment group than in control group,with statistically significant difference(P<0.05).Conclusion For elderly lung cancer-related cough,the adjuvant therapy of Su Huang cough capsule is capable of improving human immune and pulmonary function,relieving cough.
作者
余秋里
樊霞云
YU Qiuli;FAN Xiayun(Department of Respiratory Medicine,The People's Hospital of Rugao,Rugao,Jiangsu 226500;不详)
出处
《河北中医》
2021年第11期1818-1821,共4页
Hebei Journal of Traditional Chinese Medicine
基金
南通市卫生健康委员会医学科研项目(编号:MSZ1844)。
关键词
肺肿瘤
咳嗽
中成药
胶囊
Lung cancer
Cough
Chinese patent medicines
Capsule
