摘要
目的探讨康复新液与美沙拉嗪联合治疗对溃疡性结肠炎患者血清肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)、白细胞介素-6(IL-6)水平,凝血功能及免疫功能的影响。方法按照随机数字表法将2019年1月至2021年1月宜兴市中医医院收治的60例溃疡性结肠炎患者分为对照组与观察组。对照组30例患者采用美沙拉嗪治疗,观察组30例患者在对照组治疗的基础上联合康复新液灌肠治疗,两组患者均进行4周的治疗。比较治疗后两组患者临床疗效,治疗前后炎性因子指标(TNF-α、IL-8、IL-6)水平、凝血功能指标[凝血酶原时间(PT)、血小板计数(PLT)、纤维蛋白原(FIB)]水平,以及T淋巴细胞亚群指标(CD3^(+)、CD4^(+)、CD8^(+)百分比,CD4^(+)/CD8^(+)比值)水平。结果观察组患者临床总有效率显著高于对照组;治疗后两组患者血清TNF-α、IL-8、IL-6水平、血浆PLT与观察组患者FIB水平、CD8^(+)百分比均显著低于治疗前,且观察组均显著低于对照组;治疗后两组患者血浆PT均显著延长,且观察组显著长于对照组;而CD3^(+)、CD4^(+)百分比及CD4^(+)/CD8^(+)比值水平均显著高于治疗前,且观察组均显著高于对照组(均P<0.05)。治疗后对照组患者FIB低于治疗前,但差异无统计学意义(P>0.05)。结论溃疡性结肠炎患者采用康复新液联合美沙拉嗪治疗可有效降低患者机体炎性因子水平,改善机体凝血功能,调节T淋巴细胞亚群,提高免疫功能,治疗效果显著。
Objective To explore the effects of Kangfuxin solution combined with mesalazine on the serum tumor necrosis factor-α(TNF-α),interleukin-8(IL-8)and interleukin-6(IL-6)levels,coagulation function and immune function of patients with ulcerative colitis.Methods A total of 60 patients with ulcerative colitis admitted to Yixing Traditional Chinese Medicine Hospital from January 2019 to January 2021 were divided into the control group and the observation group according to the random number table method.30 patients in the control group were treated with mesalazine,and 30 patients in the observation group were treated combined with Kangfuxin solution on the basis of the treatment of patients in the control group,and both groups were treated for 4 weeks.The clinical efficacy of patients in the two groups after treatment was compared,the levels of inflammatory factor indexes(TNF-α,IL-8,IL-6)and coagulation function indexes[prothrombin time(PT),platelet count(PLT),fibrinogen(FIB)],and T lymphocyte subset indicators(CD3^(+),CD4^(+),CD8^(+)percentage,CD4^(+)/CD8^(+)ratio)levels before and after treatment of patients in the two groups were compared.Results The total clinical effective rate in the observation group was significantly higher than that in the control group;the serum TNF-α,IL-8,IL-6 levels,plasma PLT levels and CD8^(+)percentage of patients in the two groups,and FIB levels of patients in the observation group after treatment were significantly lower than those before treatment,and the observation group was significantly lower than the control group;the plasma PT of patients in the two groups after treatment significantly prolonged,and the observation group was significantly longer than the control group;while the percentage of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)ratio of patients in the two groups after treatment were significantly higher than those before treatment,and the observation group was significantly higher than the control group(all P<0.05);the FIB of patients in the control group was lower than that before treatment,but the difference was not statistically significant(P>0.05).Conclusion Kangfuxin solution combined with mesalazine in the treatment of patients with ulcerative colitis can effectively reduce the level of inflammatory factors,improve the patient’s coagulation function,regulate the T lymphocyte subsets,and enhance the immune function,and the treatment effect is remarkable.
作者
陈晖
单君康
CHEN Hui;SHAN Junkang(Department of Spleen and Gastroenterology,Yixing Traditional Chinese Medicine Hospital,Wuxi,Jiangsu 214200,China)
