摘要
目的:研究维生素C对经皮冠状动脉介入治疗(PCI)术后口服双联抗血小板(DAPT)药物所致非活动性出血的疗效。方法:选择在我院门诊就诊的PCI术后口服DAPT药物致出现皮下瘀斑的冠心病患者共159例,患者被随机分成维生素C组77例(口服维生素C片0.2g/次,3次/d),安慰剂组82例(继续口服DAPT基础上,口服安慰剂),治疗一个月。分别在治疗7d、14d时评估治疗效果。结果:与安慰剂组比较,维生素C组7d后皮下瘀斑治疗总有效率(79.27%比92.21%)、14d后皮下瘀斑治愈率(81.7%比94.8%)均显著提高,皮下瘀斑消退平均时间[(8.63±2.85)d比(6.63±2.85)d]显著缩短(P<0.05或<0.01)。结论:口服维生素C可显著减少口服双联抗血小板药物患者非活动性出血。
Objective:To study therapeutic effect of vitamin C on inactive bleeding caused by oral duplex antiplatelet(DAPT)after percutaneous coronary intervention(PCI).Methods:A total of 159 patients with coronary heart disease and subcutaneous ecchymosis(SE)caused by oral DAPT after PCI who visited our outpatient department were randomly divided into vitamin C group(n=77,received vitamin C tablet 0.2g/time,three times/d)and placebo group(n=82,received oral placebo based on continuous oral DAPT treatment),both groups were treated for one month.Therapeutic effect was assessed on 7d and 14d during treatment.Results:Compared with placebo group,there were significant rise in total effective rate of SE on 7d(79.27%vs.92.21%),cure rate of SE on 14d(81.7%vs.94.8%),and significant reduction in SE degrade mean time[(8.63±2.85)d vs.(6.63±2.85)d]in vitamin C group,P<0.05 or<0.01.Conclusion:Oral administration of vitamin C can significantly decrease inactive bleeding in patients who oral DAPT.
作者
郑艳芳
郭军霞
刘辉
张永春
龙敬宁
范振平
ZHENG Yan-fang;GUO Jun-xia;LIU Hui;ZHANG Yong-chun;LONG Jin-ning;FAN Zhen-ping(Department of Cardiology,First Affiliated Hospital of Xinxiang Medical College,Xinxiang,Henan,453100,China)
出处
《心血管康复医学杂志》
CAS
2022年第1期42-46,共5页
Chinese Journal of Cardiovascular Rehabilitation Medicine
基金
河南省医学科技攻关计划(联合共建)项目(LHGJ20190435)。
