摘要
目的综合性评价雷公藤多苷联合氨甲蝶呤对类风湿性关节炎患者的临床效果。方法选取自2018年6月至2019年6月于塔城地区人民医院全科医学科病房住院并接受治疗的类风湿性关节炎患者60例,入组病例均采用信封法随机分为对照组和试验组。对照组30例,应用雷公藤多苷口服治疗,试验组30例,在对照组的基础上联合氨甲蝶呤口服治疗。观察两组患者治疗前后关节疼痛度、WOMAC关节评分、晨僵时间及类风湿因子水平、临床有效率变化情况。结果经临床治疗,试验组WOMAC指数(35.38±5.36),类风湿因子(66.84±26.52)IU/mL,疼痛程度(2.18±0.44),晨僵时间(53.73±15.64)min,对照组WOMAC指数(46.77±7.48),类风湿因子(98.41±32.26)IU/mL,疼痛程度(4.35±0.63),晨僵时间(61.29±20.38)min,试验组总有效率96.67%显著高于对照组80.00%,试验组各项指标均优于对照组,有统计学意义(P<0.05)。结论雷公藤多苷联合氨甲蝶呤口服治疗可有效控制类风湿性关节炎患者炎性细胞活性,抑制嘌呤及嘧啶核苷酸的合成与释放,缩短晨僵时间以改善关节活动功能,药物联合用药临床效果显著,值得临床推广。
Objective To comprehensively evaluate the clinical effects of tripterygium glycosides combined with methotrexate on patients with rheumatoid arthritis.Methods Sixty patients with rheumatoid arthritis were enrolled.The enrolled cases were randomly divided into control group and experimental group by the envelope method.Thirty patients in the control group were treated with tripterygium glycosides orally,and 30 patients in the experimental group were treated with methotrexate on the basis of the control group.The changes of joint pain degree,WOMAC joint score,morning stiffness time,level of rheumatoid factor,and clinical effective rate of the two groups of patients before and after treatment were observed.Results After clinical treatment,the experimental group WOMAC index(35.38±5.36),rheumatoid factor(66.84±26.52)IU/mL,pain level(2.18±0.44),morning stiffness time(53.73±15.64)min,control group WOMAC index(46.77±7.48),rheumatoid factor(98.41±32.26)IU/mL,pain level(4.35±0.63),morning stiffness time(61.29±20.38)min,the total effective rate of the experimental group 96.67%was significantly higher than that of the control group 80.00%.All indexes in the experimental group were better than those in the control group,with statistical significance(P<0.05).Conclusion The oral administration of tripterygium glycosides combined with methotrexate can effectively control the inflammatory cell activity,inhibit the synthesis and release of purine and pyrimidine nucleotides,the clinical effect worthy of clinical promotion.
作者
李云
高文昌
LI Yun;GAO Wenchang(Department of General Medicine,Tacheng District People's Hospital,Tacheng 834700,China)
出处
《中国医药指南》
2022年第6期61-64,68,共5页
Guide of China Medicine
