摘要
目的:探讨血清同型半胱氨酸(Hcy)、甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)水平与早期先兆流产孕妇预后的相关性。方法:选取2020年7月~2021年5月期间某院收治的早期先兆流产孕妇81例设为研究组,另选取同期内健康妊娠孕妇81例设为对照组,比较两组血清Hcy、TPOAb、TGAb水平变化。对研究组孕妇随访至妊娠结束,根据妊娠预后分为继续妊娠组和流产组两个亚组,单因素和多因素logistics回归分析早期先兆流产患者出现不良预后的危险因素,绘制ROC曲线分析血清Hcy、TPOAb、TGAb水平单独和联合应用预测妊娠预后的价值。结果:研究组孕妇血清Hcy、TPOAb、TGAb水平显著高于对照组(P<0.05);继续妊娠组和流产组患者在年龄、产次、Hcy、TPOAb、TGAb等指标上均具有统计学意义(P<0.05);血清Hcy、TPOAb、TGAb水平升高是先兆流产患者发生不良妊娠预后的独立危险因素(P<0.05);单独Hcy、TGAb、TPOAb及三者联合预测先兆流产患者不良妊娠结局的AUC分别为0.512、0.702、0.731、0.819,三者联合预测的灵敏度和特异性分别为82.78%和79.89%。结论:早期先兆流产孕妇血清Hcy、TGAb和TPOAb水平显著高于健康妊娠孕妇;流产孕妇血清Hcy、TGAb和TPOAb水平显著高于继续妊娠孕妇,其水平变化与先兆流产及不良妊娠预后密切相关。三者联合检测可有助于早期预测先兆流产患者不良妊娠预后的发生,以便临床给予合理干预,降低不良妊娠发生率。
Objective:To investigate the relationship between serum homocysteine(Hcy),thyroid peroxidase antibodies(TPOAb),thyroglobulin antibodies(TGAb)levels and the prognosis of pregnant women with early threatened abortion.Methods:81 pregnant women with early threatened abortion admitted to a hospital from July 2020 to May 2021 were selected as the study group,and 81 healthy pregnant women during the same period were selected as the control group.The changes of serum Hcy,TPOAb,and TGAb levels in the two groups were compared.The pregnant women in the study group were followed up to the end of pregnancy.According to the prognosis of pregnancy,they were divided into two subgroups:the continued pregnancy group and the abortion group.The risk factors for poor prognosis in patients with early threatened abortion were analyzed by univariate and multivariate logistics regression,and the value of Hcy,TPOAb and TGAb levels alone and in combination in predicting the prognosis of pregnancy was analyzed by drawing the ROC curve.Results:The serum levels of Hcy,TPOAb and TGAb in the study group were significantly higher than those in the control group(P<0.05).The difference in age,parity,Hcy,TPOAb,TGAb and other indicators between the continued pregnancy group and the abortion group was statistically significant(P<0.05).The elevated serum levels of Hcy,TPOAb,and TGAb were the independent risk factors for poor pregnancy prognosis in patients with threatened abortion(P<0.05).The AUCs of Hcy,TGAb,TPOAb alone and in combination in predicting adverse pregnancy outcomes in threatened abortion patients were 0.512,0.702,0.731,and 0.819,respectively.The sensitivity and specificity of prediction of the three in combination were 82.78%and 79.89%,respectively.Conclusion:The serum Hcy,TGAb and TPOAb levels of pregnant women with early threatened abortion are significantly higher than those of healthy pregnant women;The serum Hcy,TGAb and TPOAb levels of pregnant women with abortion are significantly higher than those with continued pregnancy,the changes in these levels are closely related to threatened abortion and poor pregnancy prognosis.The combined detection of the three can help early predict the occurrence of poor pregnancy prognosis in patients with threatened abortion,facilitate reasonable clinical intervention,and reduce the incidence of adverse pregnancy.
作者
陈爱兰
罗婕妤
曾小变
Chen Ailan;Luo Jieyu;Zeng Xiaobian(Department of Obstetrics,No.2 Affiliated Hospital of Guangdong Medical University,Zhanjiang 524000;Department of Clinical Laboratory,No.2 Affiliated Hospital of Guangdong Medical University,Zhanjiang 524000)
出处
《数理医药学杂志》
CAS
2022年第2期159-162,共4页
Journal of Mathematical Medicine
基金
湛江市科技计划项目“血清Hcy、TPOAb、TGAb水平与早期先兆流产孕妇预后的相关性研究”(项目编号:2020B01100)。
